珠海市斗门区人群甲型H1N1流感病毒抗体影响因素分析

Analysis on Influencing Factors of Antibodies Against Influenza A(H1N1) Among the Residents in Doumen District,Zhuhai City

目的了解珠海市斗门区人群甲型H1N1流感病毒感染状况及抗体水平,探讨影响普通人群血清甲型H1N1流感病毒抗体阳性的因素。方法采用多阶段随机抽样方法,从斗门区2个镇选取480人进行问卷调查,并采集血液标本进行甲型H1N1流感病毒血凝抑制(HI)检测。结果甲型H1N1流感抗体阳性人数为110人,阳性率为22.92%(110/480)。单因素和多因素二项Logistic分析均显示职业、接种甲型H1N1流感疫苗、调查前曾患过感冒与血清甲型H1N1流感病毒抗体阳性有关。结论珠海市斗门区人群甲型H1N1流感病毒抗体水平不高。接种甲型H1N1流感疫苗是预防甲型H1N1流感的重要手段。

Objective To investigate the infection status and antibody level of influenza A（H1N1）,and explore the factors correlated to positive serum antibodies against influenza A（H1N1） virus among the residents in Doumen District,Zhuhai City. Methods Multistage random sampling method was used to select 480 individuals from 2 towns of Doumen District.Blood samples were collected for H1N1 influenza virus hemagglutinin-inhibition（HI） test;meanwhile,the questionnaire survey was conducted. Results The antibody against influenza A（H1N1） of 110 in 480 subjects showed positive,the seroprevalence was 22.92%（110/480）.Univariate and multivariate Logistic regression analysis showed that factors such as occupation,influenza A（H1N1） vaccine immunization,history of common cold were all associated with positive serum influenza A（H1N1） antibody. Conclusions Antibody level of influenza A（H1N1） was low.The influenza A（H1N1） vaccine is the most effective way to obtain protective antibodies of influenza A（H1N1）.