100例肺癌脑转移患者放化疗临床疗效分析

Analysis on Clinical Therapeutic Effect of Radiotherapy and Chemotherapy in 100 Lung Cancer Patients with Brain Metastases

目的对肺癌脑转移患者接受放疗治疗进行临床观察分析,研究放疗方法的治疗效果。方法对本院2007年4月-2008年4月肺癌脑转移患者100例,根据患者自愿选择治疗方式的情况将其分成两组,分别给予不同方法治疗进行回顾分析。将其中42例临床治疗时选择单纯接受放射治疗的患者设为对照组;另一组58例患者设为研究组,临床在对其进行放射治疗的同时再配合化疗方法进行联合治疗。根据两组患者临床接受不同方式治疗肺癌脑转移的疗效进行对比分析。结果研究组与对照组患者近期治疗效果观察比较差异无统计学意义(P>0.05),但是根据肺癌转移患者在一、两年内的生存率情况进行比较,研究组患者生存率要远高于对照组,差异有统计学意义(P<0.05)。结论通过临床对两组肺癌脑转移患者的治疗疗效进行分析可以得出,研究组患者生存期要明显高于对照组,使用放射治疗加化疗方法治疗肺癌脑转移患者可以明显延长患者的生存期,改善患者的生存环境以及质量,值得临床推广与应用。

Objective To observe and analyze the lung cancer patients with brain metastases who treated with radiotherapy,and to study the therapeutic effect of radiotherapy. Methods We retrospectively analyzed the clinical data of 100 lung cancer patients with brain metastases hospitalized in the Second People＇s Hospital of Hunan Province from April,2007 to April,2008.According to the principle of voluntary choice of medication,the patients were divided into two groups.42 patients treated with radiotherapy only were served as control group,and 58 patients treated with concurrent radiotherapy and chemotherapy served as study group.And the therapeutic efficacy of the two groups were compared and analyzed. Results No statistically significant difference was found in short-term therapeutic effects between the two groups（P0.05）,but according to the one-or two-year survival rate of the patients,the survival rate of study group was significantly higher than that of control group,and the difference was statistically significant（P0.05）. Conclusions The results suggest that the survival rate of study group is significantly higher than that of control group.Concurrent application of radiotherapy and chemotherapy can significantly prolong the survival time of lung cancer patients with brain metastases and improve the living environment and quality of the patients.It is worth popularizing in clinical practice.