湘南地区临床分离大肠埃希菌的耐药性变迁

Changes of Antibiotic Resistance of Escherichia coli Isolated from Clinical Samples in the South of Hunan Province

目的了解湘南地区大肠埃希菌的耐药性,为临床用药提供参考。方法采用WHONET5.3软件对2008-2010年郴州地区11所医院(9所二级医院,2所三级医院)临床标本中分离的2 584株大肠埃希菌的耐药性进行回顾性统计分析。结果湘南地区2008-2010年三年间共检出大肠埃希菌2 584株,在药敏结果中除碳青霉烯类抗菌药物外,其余抗菌药物中产ESBLs菌株较非产ESBLs菌株的耐药性明显增高,差异有统计学意义(P<0.01)。结论应加强对大肠埃希菌的耐药性监测,合理规范使用抗菌药物。

Objective To investigate the drug resistance of Escherichia coli in southern region and provide reference for clinical medication. Methods using WHONET5.3 software to analysis the 2,584 strains of Escherichia coli which isolated from clinical samples that collected by 11 hospitals in Chenzhou from 2008 to 2010. Results There were 2,584 strains of Escherichia coli detected in the last three years.Among the results of antimicrobial susceptibility test,the strains which produced extended-spectrum beta-lactometers（ESBLs） in the other antibacterial drugs had more resistance than the other strains except carbon penicillium dilute,the difference was statistically significant（P0.01）. Conclusions We should strengthen the resistance monitoring of Escherichia coli and rational use of antimicrobial agents.