期刊文献+

孕妇乙型肝炎血清学模式与新生儿宫内感染的相关性分析 被引量:4

Correlation Between Serological Patterns of HBV in Pregnant Women and Intrauterine Infection
原文传递
导出
摘要 目的探讨孕妇乙型肝炎血清学感染模式与新生儿宫内感染的相关性。方法 ELISA法检测孕妇血清乙型肝炎病毒血清学标志物(HBV-M),HBsAg、HBeAg、HBeAb、HBcAb任一项阳性者,荧光定量PCR法检测脐血HBV-DNA。根据HBV-M不同模式将结果分为HBeAg(+)组、HBsAg(+)HBeAg(-)组、HBsAg(-)HBeAg(-)三组,比较各组脐血HBV-DNA阳性检出率及HBV-DNA定量结果。结果 722例受检孕妇中,93例脐血HBV-DNA检出阳性,阳性检出率为12.9%,HBeAg(+)组阳性检出率显著高于其它二组(P<0.001);三组脐血HBV-DNA对数均值分别为(4.85±1.29)、(4.35±0.98)和(3.75±0.40),HBeAg(+)组脐血DNA含量显著高于其它二组(P<0.001)。结论孕妇血清HBeAg(+)者新生儿宫内感染率较高,孕妇血清HBsAg(-)HBeAg(-)者新生儿亦存在宫内感染的可能性。 Objective To explore the correlation between serological patterns of HBV in pregnant women and intrauterine infection. Methods ELISA was used to detect the immunological markers and FQ PCR was used to detect the level of cord blood HBV-DNA.According to serological patterns of HBV,results were divided into three groups: HBeAg(+),HBsAg(+)HBeAg(-)and HBsAg(-)HBeAg(-)group.The positive rates and level of cord blood HBV-DNA were compared in three groups. Results The positive rates of HBV-DNA in cord blood were 30.9%,14.5% and 5.7% in three groups respectively,group with HBeAg positive was significantly higher than group with HBeAg negative.The logarithm of HBV-DNA level were 4.85±1.29, 4.35±0.98,and 3.92±0.55 in three groups respectively,group with HBeAg positive was significantly higher than group with HBeAg negative. Conclusions The incidence of HBV intrauterine infection is relatively high in pregnant women with HBeAg positive,while in pregnant women with HBsAg and HBeAg negative,HBV intrauterine infection is also possible.
作者 胡洪波
出处 《实用预防医学》 CAS 2011年第12期2388-2389,共2页 Practical Preventive Medicine
关键词 乙型肝炎病毒血清学模式 HBV-DNA 宫内感染 HBV serological patterns HBV-DNA Intrauterine infection
  • 相关文献

参考文献5

  • 1Elefsiniotis IS, Papadakis M, Vlahos G, et al. Clinical significance of hepatitis B surface antigen in cord blood of hepatitis B e - antigen - negative chronic hepatitis B virus- infected mothers[J ]. Intervirology, 2009,52(3) : 132 - 134.
  • 2王芳,张海涛,乔云波,于广福,李晓霞,于爱莲.乙型肝炎病毒宫内感染的流行病学研究[J].中国病原生物学杂志,2010,5(11):813-814. 被引量:1
  • 3胥庆梅.乙肝感染产妇与新生儿乙肝血清标志物检测结果分析[J].现代预防医学,2010,37(20):3858-3859. 被引量:7
  • 4Choi J, Ahn S, Park J, et al. Hepatitis B e antigen - negative mutations in the precore and core promoter regions in Korean patients [J]. J Med Virol, 2009, 81(4) : 594 - 601.
  • 5Tangkijvanich P, Sa - nguanmoo P, Mahachai V, et al. A case - control study on sequence variations in the enhancer II/core promoter/pfecore and X genes of hepatitis B virus in patients with hepatocellular carcino- ma[J]. Hepatoi Int, 2010,4(3) :577 - 584.

二级参考文献18

共引文献6

同被引文献34

  • 1王雪霞.妊娠合并乙型肝炎病毒感染对母儿预后的影响[J].山东医药,2005,45(32):75-75. 被引量:3
  • 2彭树道 李明 胡国良.乙肝病毒标志物与HBV-DNA含量关系探讨.中国民康医学杂志,2010,15(7):236-237.
  • 3郭彩娇 杨红玲 陈子娟.乙肝血清标志物与其HBV-DNA含量的对比分析.中国妇幼保健杂志,2010,1(1):70-72.
  • 4Su HX, Xu DZ, Li D, et al. Heterogeneity analysis of the hepatitis B vir- us genome in intrauterine infection [J]. J Med Virol, 2005,77 : 180 - 187.
  • 5陈学民,凡任芝.定量PCR检NHBV-DNA与HBV血清标志物的相关性[J].临床输血与检验,2010,8(25):168-169.
  • 6Gaeta GB,Stornaiuole G,Precone DF,et al.Epideniologica1 and clini cal burden of chronic hepatitis B virus/hepatitis C virus infection.A nulticenter Italian study[J].J Hepatol,2007,39 (7):1036-1041.
  • 7Brunetto MR, Moriconi F, bo,Ano F, et al. Hepatitis B virus sur- face antigen levels: a guide to sustained response to pegintcrferon alfa-2a in HBeAg-negative chronic hepatitis B [ J ]. Hepatology, 2009,49 (4) : 1141-1150.
  • 8Li D, Xu DZ, Choi BC, et al. Preliminary Study on the efficacy and safety of lamivudine and interferon alpha therapy in decreasing serum HBV DNA level in HBV positive transgenic mice during pregnancy [ J ]. J Med Virol, 2005,76 (2) :203-207.
  • 9邵中军,李晶华,徐德忠,姜庆五,徐剑秋.HBV宫内感染与孕期使用乙肝免疫球蛋白关系[J].中国公共卫生,2008,24(2):135-136. 被引量:13
  • 10赵秀英,陈俊梅,辛永梅,孙桂珍.不同方法检测乙型肝炎病毒血清标志物的差异[J].肝脏,2008,13(4):303-305. 被引量:21

引证文献4

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部