期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Th17细胞与肿瘤 被引量：4

Thl7 cells and tumor
原文传递
导出
摘要 Th17细胞是一类CD4^＋效应T细胞。研究发现Thl7细胞及其相关细胞因子存在于许多肿瘤中，并在炎症相关性肿瘤中发挥重要作用，但对Th17细胞在肿瘤微环境中的分化表达、免疫调控机制及功能效应仍不明确。 Thl7 cells are CD4^＋ effector T cells. Many studies have confirmed that Thl7 cells and their related cytokines exist in many kinds of tumors, and play critical roles in inflammation related tumors. But the expression and differentiation in tumor microenvironment, the immune regulation mechanisms and functional effects of Thl7 cells remains controversial.
作者 何宋兵 郑丁铖 汪良 李德春
机构地区 苏州大学附属第一医院普外科
出处 《国际肿瘤学杂志》 CAS 2011年第12期908-910,共3页 Journal of International Oncology
基金 基金项目：江苏省医学科研计划资助项目（H201013） 江苏省研究生培养创新工程项目（CXl0B_054Z）
关键词 白细胞介素17 肿瘤 免疫调节 TH17细胞 Interleukin-17 Neoplasms Immunomodulation Thl7 cells
分类号 R730.3 [医药卫生—肿瘤]
  • 相关文献

参考文献29

  • 1Colotta F, Allavena P, Sica A, et al. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis, 2009, 30 (7) : 1073-1081.
  • 2Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell, 2011, 144(5) :646-674.
  • 3Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol, 2005, 6(11) :1133-1141.
  • 4Dong C. TH17 ceils in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol, 2008, 8 (5) :337-348.
  • 5Su X, Ye J, Hsueh EC, et al. Tumor microenvironments direct the recruitment and expansion of human Thl7 cells. J Immunol, 2010, 184(3 ) : 1630-1641.
  • 6Zhu X, Mulcahy LA, Mohammed RA, et al. IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines. Breast Cancer Res, 2008, 10(6) :R95.
  • 7Wu S, Rhee KJ, Albesiano E, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med, 2009, 15(9) :1016-1022.
  • 8Kryczek I, Banerjee M, Cheng P, et al. Phenotype, distribution, generation, and functional and clinieal relevance of Thl7 cells in the human tumor environments. Blood, 2009, 114 (6) : 1141-1149.
  • 9Koyama K, Kagamu H, Miura S, et al. Reciprocal CD4^+ T-cell bal- ance of effector CD62Llow CD4^+ and CD621highCD25^+ CD4^+ regulatory T ceils in small cell lung cancer reflects disease stage. Clin Cancer Res, 2008, 14(21) : 6770-6779.
  • 10Wu C, Wang S, Wang F, et al. Increased frequencies of T helper type 17 ceils in the peripheral blood of patients with acute myeloid leukaemia. Clin Exp Immunol, 2009, 158 (2) : 199-204.

同被引文献43

  • 1邹戬.细胞因子TNF-α和TSGF在恶性肿瘤中的检测价值[J].齐齐哈尔医学院学报,2004,25(12):1343-1344. 被引量：4
  • 2Afzali B,Lombardi G,Lechler RI,et al. The role of T helper 17(Thl7 ) and regulatory T cells ( Treg) in human organ transplanta-tion and autoinlmune disease[ J]. Clin Exp Im-munol, 2007 ,148(1):32-40.
  • 3Martinez GJ, Nurieva RI, Yang XO, et al. Regulation and func-tion of proinflammatory Thl7 cells [ J]. Ann N Y Acad Sci,2008,1143:118-211.
  • 4Zhu X,Mulcahy LA,Mohammed RA,et al. IL-17 expression bybreast-cancer-associated macrophages : IL-17 promotes invasive-ness of breast cancer cell lines[ J]. Breast Cancer Res,2008,10(6): R95.
  • 5Zhang JP,Yan J,Xu J, et al. Increased intratumoral IL-17-pro-ducing cells correlate with poor survival in hepatocellular carcino-ma patients[J]. J Hepatol, 2009, 50(5) : 980-989.
  • 6Zhang B, Rong G, Wei H, et al. The prevalence of Thl7 cellsin patients with gastric cancer[ J] . Biochem Biophys Res Com-mun,2008, 374(3) : 533-537.
  • 7He SB, Fei M, Wu YG, et al. Distribution and Clinical Signifi-cance of Thl7 Cells in the Tumor Microenvironment and Periph-eral Blood of Pancreatic Cancer Patients [ J] . Int J Mol Sci,2011,12(11):7424-7437.
  • 8Miyahara Y, Odunsi K, Chen W, et al. Generation and regula-tion of human CD4 + IL-17 -producing T cells in ovarian cancer[J]. Proc Natl Acad Sci USA, 2008,105(40) ; 15505-15510.
  • 9Sfanos KS, Bruno TC, Maris CH, et al. Phenotypic analysis ofprostate-infiltrating lymphocytes reveals Thl7 and Treg skewing[J]. Clin Cancer Res, 2008, 14(11): 3254-3261.
  • 10Kuang DM, Peng C, Zhao Q, et al. Activated monocytes in peritu-moral. stroma of hepatocellular carcinoma promote expansion ofmemoy T helperl7 cells[J]. Hepatology, 2010,51(1) : 154-164.

引证文献4

二级引证文献28

国际肿瘤学杂志
2011年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部