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食管癌治疗敏感基因单核苷酸多态性 被引量：1

Therapeutic sensitivity gene SNP in esophageal cancer
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摘要 研究显示食管癌治疗过程中表现的个体差异与遗传多态性有密切关系。已证实顺铂及5氟尿嘧啶（5-FU）代谢相关基因、凋亡及血管生成相关基因单核苷酸多态性与食管癌治疗敏感性密切相关。 Genetic polymorphisms are thought to be associated with the individual difference in the esophageal cancer treatment. A large number of evidences show that 5-FU and cisplatin metabolism, apoptosis and angiogenesis related gene SNPs are associated with the therapeutic sensitivity of esophageal cancer.
作者 季文豪 凌志强 毛伟敏
机构地区 浙江省肿瘤医院浙江省肿瘤研究所
出处 《国际肿瘤学杂志》 CAS 2011年第12期923-926,共4页 Journal of International Oncology
基金 基金项目：浙江省自然科学基金资助项目（Y2080749,Y2091110） 卫生部.浙江省重大科研基金资助项目（WKJ2010-2-004） 浙江省重大科技专项计划项目（2011C13039-1）
关键词 食管肿瘤 单核苷酸多态性 Esophageal neoplasms Single nueleotide polymorphism
分类号 R735.1 [医药卫生—肿瘤]
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参考文献25

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同被引文献24

  • 1Hong L,Li S,Han Y. Angiogenesis-related molecular targets in esophageal cancer[J].{H}Expert Opinion on Investigational Drugs,2011,(5):637-644.
  • 2Norguet E,Dahan L,Seitz JF. Targetting esophageal and gastric cancers with monoclonal antibodies[J].Curr Top Med Cbem,2012,(15):1678-1682.
  • 3Banzi A,Lenz HJ. Angiogenesis-related agents in esophageal cancer[J].{H}Expert Opinion on Biological Therapy,2012,(10):1335-1345.
  • 4Jiang JT,Zhang LF,Zhou B. Relationships of uPA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis[J].Asian Pac J Cancer Prey,2012,(7):3379-3383.
  • 5Chen M,Cai E,Huang J. Prognostic value of vascular endothelial growth factor expression in patients with esophageal cancer:a systematic review and meta-analysis[J].{H}Cancer Epidemiology Biomarkers & Prevention,2012,(7):1126-1134.
  • 6Lin C,Song L,Gong H. Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer[J].{H}CANCER RESEARCH,2013,(12):3638-3648.
  • 7Sakurai T,Okumura H,Matsumoto M. The expression of LC-3 is related to tumor suppression through angiogenesis in esophageal cancer[J].{H}MEDICAL ONCOLOGY,2013,(4):701.
  • 8Chen MF,Chen PT,Lu MS. IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus[J].{H}Molecular Cancer Therapautics,2013.26.
  • 9Wang LD,Zhou FY,Li XM. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54[J].{H}Nature genetics,2010,(9):759-763.
  • 10Abnet CC,Freedman ND,Hu N. A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma[J].{H}Nature genetics,2010,(9):764-767.

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国际肿瘤学杂志
2011年 第12期

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