雌激素水平与产后抑郁症的相关性研究

目的:探讨雌二醇水平与产后抑郁症的关系。方法:对256例产后42天内的产妇,应用爱丁堡产后抑郁量表(EPDS)、Beck抑郁量表(BDI)、一般健康问卷(GHQ)进行评定。以EPDS总分≥13分为产后抑郁症诊断标准,并分为抑郁症组与正常组,应用放射免疫法测定两组妇女血浆雌二醇水平。结果:发生率:产后抑郁症发生率15.6%,发生率最高的年龄段30岁以上24.6%,23岁以下发生率最低11.1%,两者比较,差异有统计学意义(P<0.01)。中专及以上学历的发生率较高21.3%,文化程度为小学及初中者发生率7.9%,两者比较,差异有统计学意义(P<0.01)。生物学指标测定:抑郁症组妇女雌二醇水平64.39±822pmol/L,明显低于正常组的126.18±7.45pmol/L,两组比较,差异有统计学意义(P<0.01)。雌二醇水平与EPDS、BDI、GHQ量表分值呈负相关(相关系数分别为-0.54,-0.75,-0.35;P<0.05),即雌二醇水平越低,产后EPDS、BDI、GHQ分值越高。结论:EPDS、BDI、GHQ量表评定可作为筛选产后抑郁症的依据,雌二醇的水平测定可为产后抑郁症的诊断提供客观的生物学指标。

Objective：To explore the relation ship of estradiol（E2）.Methods：Totally 256 women within 42 days after childbirth were assessed with Edinburgh postnatal depression scale（EPDS）,Beck depression inventory（BDI）,and general health questionnaire（GHQ）,Above or equal to 13 of overall score of EPDS was the diagnosis standard of postpartum depression,and the women tested were divided into depression group and normal group accordingly,using the reagent box of radio immunoassay to test estradiol.Results：Incidence：the incidence of postpartum depression wos 15.6%.The highest incidence occurred in patients above 30（13.8%）;the incidence among women under 23 years old was lowest（11.0%）,with a significant difference between them（P〈0.01）;the incidence in persons with a bachelor degree an above（21.3%）was higher than that of persons with a lower degree of education（7.9%）,with a significant difference between the two groups.Biological indicator：the levels of E2 64.39±8.22pmol/L,were significantly lower than those in the normal guoup 126.18±7.45pmol/L,P〈0.01.The levels of E2 was negatively correlatde with the score of EPDS,BDI,GHQ（P〈0.05）.Conclusions：Evaluation scales such as EPDS,BDI,and GHQshould be used to screen for postpartum depression.The measurement of estradiol level can be used as biological objectove indicators for prevention and treament of postpatum depression.