摘要
目的研究乳酸环丙沙星温度敏感眼用凝胶的体外释放规律。方法采用无膜溶出模型考察凝胶溶出规律,采用紫外分光光度法进行药物含量测定。结果乳酸环丙沙星温度敏感眼用凝胶溶蚀和药物释放为零级动力学过程,凝胶溶蚀和药物释放呈良好的线性相关。结论凝胶溶蚀是决定药物释放的主要因素。
Objective To study the in vitro release of Ciprofloxacin Lactate In Situ Thermosensitive Ocular Gels. Methods The membraneless model was used to study the rule of gel erosion and drug release simultaneously. The content of ciprofloxacin was determined by UV spec- trophotometry. Results The drug release and gel erosion was followed the zero-order kinetics. The linear correlation was found between drug release and gel erosion. Conclusion Gel erosion is the main factor determining the drug release from the gel.
出处
《中国药业》
CAS
2011年第24期24-25,共2页
China Pharmaceuticals
关键词
乳酸环丙沙星
温度敏感眼用凝胶
紫外分光光度法
体外释放
ciprofloxacin lactate
in situ thermosensitive ocular gels
UV spectrophotometry
in vitro release
