抗癌活性化合物黄酮的合成研究

Synthesis Study of Anti-Cancer Active Compound Flavonoid

目的探索操作简单、收率高的抗癌活性化合物黄酮的合成方法。方法研究路易斯酸催化1-(2-羟基)-3-芳基-1,3-丙二酮环合的反应条件。结果在温和条件下,使用Ga(OTf)3催化1-(2-羟基)-3-芳基-1,3-丙二酮的环合反应,收率高、副反应少。结论该方法应用前景广阔。

Objective To study a simple and high-yield synthesis method of anti-cancer active compound flavonoids. Methods To study the reaction condition of cyclization of 1 -（2-hydroxy） -3- aryl- 1, 3-propanedione catalyzed by Lewis acid. Results Under mild conditions, Ga （OTf）3 as catalyst was used to catalyze the cyclization reaction of 1- （2-hydroxy）-3-aryl-1, 3-propanedione with high yield of fiavonoids and less side reactions. Conclusion This method has wide application prospect.