508例婴儿血铅水平与6种矿物质及骨代谢的相关性研究

Research of correlation between blood lead level and six kinds of minerals and bone metabolism of 508 infants

目的:探讨婴儿血铅水平与6种矿物质及骨碱性磷酸酶的关系。方法:采用北京博辉公司生产的BH2100及BH5100原子吸收光谱分析仪测定分析,对开远市508例婴儿进行血铅、镉及血锌、铁、钙、镁、铜的测定;骨碱性磷酸酶(NBAP)测定采用ZS-isoAP骨源性碱性磷酸酶试剂盒;测定结果进行等级相关检验分析(Spearman法)。结果:508例婴儿中,血铅含量最低值为10μg/L,最高值为223μg/L,铅中毒检出率为13.78%。血铅水平与铁、钙、镁、铜和骨碱性磷酸酶差异无统计学意义(P>0.05),与锌、镉呈正相关(P<0.05)。结论:铅中毒会使锌、镉的代谢紊乱,导致婴儿锌、镉水平增加。

Objective：To explore the relationship between blood lead level of infants and six kinds of minerals and bone alkaline phosphatase. Methods：BH2100 and BH5100 atomic absorption spectrum analyzers provided by Beijing Bohui company were used to detect the levels of blood lead,cadmium,zinc,iron,calcium,magnesium and copper in 508 infants from Kaiyuan city;the level of bone alkaline phosphatase was detected by ZS-isoAP bone alkaline phosphatase kit;the detection results were analyzed by Spearman method. Results：Among 508 infants,the lowest and highest values of blood lead were 10 μg/L and 223 μg/L,respectively;the detection rate of lead poisoning was 13.78%.There was no correlation between blood lead level and iron,calcium,magnesium,copper and bone alkaline phosphatase（P〈0.05）,but blood lead level was positively correlated with zinc and cadmium（P〈0.05）. Conclusion：Lead poisoning may cause metabolic disorders of zinc and cadmium,induce the increases of zinc and cadmium levels.