新型三唑醇类化合物的合成及抗真菌活性研究

Synthesis and antifungal activity of the novel triazole compounds

目的以氟康唑为先导化合物，设计合成新的三唑醇类化合物，并研究其抗真菌活性。方法引入较大基团的N，N-二取代侧链结构，合成一系列目标化合物，所有化合物结构均经MS、1H NMR等谱确证；选择8种真菌为实验菌株，测定其体外抗真菌活性，、结果合成了18个未见文献报道的目标化合物，化合物对所选真菌均表现出厂一定的抑菌活性，结论引入较大幕团的N，N-二取代侧链结构对抗真菌活性影响较大。

Objective To design the synthesis and evaluate the antifungal active of the novel triazole compounds based on the structure of flucnnazole. Methods The big N,N-disubstituted group was introduced and a series of compounds were synthesized, all of them were confirmed by MS arid 1H NMR, et al. The antifungal activity were also evaluated against the eight common pathogenic fungi. Results Eighteen compounds were synthesized,which exhihited activity against fungi tested. Conclusion The big N, N-disuhstituted group introduced to the side chain could affected the antifungal activity.