期刊文献+

冠心病与瘦素、Hs-CRP的相关性分析 被引量:1

A Correlative investigation of serum leptin and Hs-CRP in patients with coronary artery disease
下载PDF
导出
摘要 目的探讨瘦素(leptin)以及超敏炎症C-反应蛋白(Hs-CRP)水平在冠心病中的相关性及意义。方法选择冠心病患者98例,其中心绞痛患者56例,心肌梗死42例,同时选取同期健康30例作为对照组,检测其24h内瘦素与超敏C反应蛋白(Hs-CRP)水平。结果与对照组相比,冠心病组瘦素与Hs-CRP水平升高,差异有统计学意义(P<0.05)。且心肌梗死组瘦素与Hs-CRP水平高于心绞痛组。结论检测冠心病患者血清瘦素、Hs-CRP水平的变化对冠心病的发生与发展均具有重要的临床价值。 Objective To study the relastionship between serum leptin and Hs-CRP in coronary artery disease(CAD).Methods Ninty eight CAD patients were involved,of whom,56 with angina and 42 with acute myocardial infarction(AMI) and thirty were control group.The serum Hs-CRP and leptin were detected at 24 hours after admission.Results Leptin and Hs-CRP levels in those with angina and AMI were higher than thatof the control group.And Leptin,Hs-CRP levels were higher in AMI than angina group.Conclusion The serum levels of leptin and Hs-CRP are closely related to the diseases processof CHD and are of great clinical importance.
作者 王岩
出处 《中国实用医药》 2011年第32期49-50,共2页 China Practical Medicine
关键词 冠心病 瘦素 超敏C-反应蛋白 Coronary diseases Leptin Hs-CRP-
  • 相关文献

参考文献7

二级参考文献24

  • 1刘成玉,王红巧.不稳定型心绞痛病人血管性血友病因子与C-反应蛋白水平的变化[J].齐鲁医学杂志,2004,19(4):327-329. 被引量:3
  • 2王霞.高尿酸血症与冠状动脉粥样硬化性心脏病的关系[J].中国医学工程,2005,13(5):480-482. 被引量:9
  • 3Meister B. Control of food intake via leptin receptors in the hypothalamus[J]. Vitam Horm, 2000, 59:265 - 304.
  • 4Stenvinkel P. Leptin and its clinical implications in chronic renal failure[J]. Miner Electrolyte Metab, 1999, 25(4 - 6) :298 - 302.
  • 5Allen D K, Gerald W B, Lisa M C, et al. Leptin is a four - helix bundle:secondary structure by NMR[J]. FEBS Letters, 1997, 407(2) :239 - 42.
  • 6Imagawa K, Numata Y, Katsuura G, et al. Structure - function studies of human hptin[J] .J Biol Chem, 1998, 273(52) :35245 -35249.
  • 7Loffreda S, Yang S Q, Lin H Z, et al. Leptin regulates proinflammatory immune responses[J]. FASEB J, 1998,12( 1 ) : 57 - 65.
  • 8Kirchgessner A L, Liu M. Orexin synthesis and response in the gut[J]. Neuron, 1999, 24(4) :941 - 951.
  • 9Wolf G. Orexins: a newly discovered family of hypothalamic regulators of food intake[J]. Nutr Rev, 1998, 56(6) : 172 - 173.
  • 10Sakurai T. Orexins and orexin receptors: implication in feeding behavior[J ]. Regul Pept, 1999, 85 ( 1 ) : 25 - 30.

共引文献31

同被引文献11

  • 1Lieb Wv Sullivan LM.Harris 1;B.et al. Plasma leptin lev?els and incidence of heart fail ure , cardiovascular disease, and total mortality in elderly individuals[J]. Diabetes Care,2009,32(4) :612-616.
  • 2Soderberg S,Ahren B,JanssonJI,et al. Leptin is associat?ed with increased risk of cardial infraction[J].J Infem Med,1999,246(4):409.
  • 3Sattar N, Wannamethee G, Sarwar N, et al. Leptin and coronary heart disease: prospective study and systematic review[J].J Am Coil Cardiol,2009 ,53(2): 167.
  • 4Couillard C, Lamarche B, Ma uriege P. et al. Leptinemia is not a risk factor for ischemic heart disease in men. Pro?spective results from the Quebec Cardiovascular Study[J]. Diabetes Care,1998,21(5) :782.
  • 5Rajendran Kv frevarajan N,Ganesan M,et al. Obesity .In?flammation and acute myocardial infarction - expression of leptin,IL-6 and high sensitivity-CRP in Chennai based population[J]. ThrombJ ,2012,100) : 13.
  • 6Ku lA. Farzaneh-Far R, Vittinghoff E, er al. Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: the Heart and Soul Study[J] . Atherosclerosis, 2011 ,217 (2) : 503.
  • 7武文峰,蔡鑫.瘦素与冠心病发病机制的研究进展[J].心血管病学进展,2008,29(3):416-418. 被引量:5
  • 8王学英,高炜,薛军,郭丽君.血浆瘦素水平与冠心病患者冠状动脉病变程度及预后的相关性分析[J].中国心血管杂志,2011,16(1):12-15. 被引量:9
  • 9吴秀娟,夏大胜,卢成志,郭倩玉,李超.血清瘦素与早发冠心病及血浆组织因子的关系[J].临床心血管病杂志,2013,29(1):11-14. 被引量:3
  • 10陈杰,张丽华,牛少辉,杨继涛.瘦素、脂肪酸合成酶、雌激素与冠状动脉血管钙化的关系[J].重庆医科大学学报,2013,38(2):194-196. 被引量:5

引证文献1

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部