高血压患者糖化血红蛋白检测的临床价值

The clinical value of hemoglobin A1c detection detection for the hospitalized non-diabetic patients with hypertension

目的:探讨高血压患者糖化血红蛋白(HbA1c)检测的临床价值。方法:对699例无糖尿病病史的住院患者,根据有无高血压病史分为高血压组(376例)与非高血压组(323例)。所有研究对象均行75 g口服葡萄糖耐量试验(OGTT),检测HbA1c、空腹血糖(FPG)、餐后2 h血糖(2h-PPG)、空腹胰岛素(FINS)、血脂及肝肾功能。2组患者又根据HbA1c水平分为HbA1c≥6.1%和HbA1c<6.1%亚组。结果:1.高血压组与非高血压组的HbA1c分别为(5.88±0.87)%,(5.58±0.97)%。2.无论血压水平如何,HbA1c≥6.1%亚组糖尿病患病比例较HbA1c<6.1%亚组均升高(P<0.05);高血压组与非高血压组相比HbA1c≥6.1%亚组糖尿病患病比例升高(P<0.05)。3.无论HbA1c水平如何,高血压组的冠心病患病比例较非高血压组均显著升高(P<0.05);高血压组的HbA1c≥6.1%亚组较HbA1c<6.1%亚组冠心病患病比例升高(P<0.05)。结论:高血压患者在HbA1c≥6.1%时糖尿病和冠心病患病比例均升高。

Objective：To explore the clinical value of HbA1c detection in hypertention patients.Methods： Six hundred and ninty-nine patients without diagnosed diabetes mellitus were divided into groups of hypertention（n=376） and non-hypertention（n=323）.All patients received 75g-oral glucose tolerance test（OGTT）,detected fasting plasma glucose（FPG） 、HbA1c 、lipids 、liver function and kidney function.According to the hemoglobin A1c（HbA1c） level,two group of patients were divided into subgroups of HbA1c ≥6.1% and HbA1c 6.1%.Results： 1.The HbA1c of hypertension group and non-hypertention group,respectively were（5.88 ± 0.87）%,（5.58 ± 0.97）%.2.The diabetes percent of HbA1c ≥ 6.1% subgroups in both groups were higher than those of the HbA1c 6.1% subgroup（P〈0.05）;the diabetes percent of HbA1c≥ 6.1% subgroup in hypertension group was higher than that of non-hypertension group（P〈0.05）.3.The coronary disease percents of the two HbA1c subgroups in hypertension group were higher than those of non-hypertension group（P〈0.05）;the coronary disease percent of HbA1c ≥ 6.1% subgroup in hypertension group was higher than that of the HbA1c 6.1% subgroup（P〈0.05）.Conclusion： The percents of diabetes and coronary disease in hypertention patients with HbA1c ≥6.1% were increased.