偏头痛患者血清降钙素原水平的变化

CHANGES OF SEURM PROCALCITONIN LEVELS IN MIGRAINE PATIENTS

目的:观察偏头痛患者血清降钙素原(PCT)水平的变化,探讨偏头痛可能的发病机制。方法:将163例偏头痛患者分成偏头痛发作期组(n=80)和偏头痛发作间期组(n=83)。根据患者有无先兆症状进一步分成四个亚组:无先兆偏头痛的发作期组(n=68)、先兆偏头痛的发作期组(n=12)、无先兆偏头痛的发作间期组(n=70)、先兆偏头痛的发作间期组(n=13)。测定每组患者血清PCT水平。结果:所有偏头痛患者中,偏头痛发作期PCT水平明显高于发作间期(P<0.01)。在无先兆偏头痛或先兆偏头痛患者中,偏头痛发作期PCT水平也分别明显高于发作间期(P<0.01)。结论:PCT可能是偏头痛发作的一个炎症标志,是偏头痛发作的潜在机制之一。

Objective： To investigate the changes of serum procalcitonin（PCT） levels in patients with migraine and the underlying mechanism of migraine.Method： 163 adult patients with migraine were divided into two main groups： migraine during headache attack period（n = 80） and migraine during headache free period（n = 83）.These patients were further divided into four subgroups according to with or without aura.The serum levels of PCT in all patients were measured.Result： PCT levels in patients with migraine during headache attack period were significantly higher than those during headache free period（P 0.01）.PCT levels in patients with migraine with aura and in patients with migraine without aura during headache attack period were also significantly higher than those during headache free period（P 0.01）.Conclusion： PCT may be an inflammatory marker for migraine attacks,and was response for one of the underlying mechanisms of migraine attacks.