趋化因子与慢性丙型肝炎关系的研究进展

Study on the relationship between chemokines and chronic hepatitis C

趋化因子是一类结构功能相似、能使细胞发生趋化作用的小分子蛋白质。研究表明趋化因子与HCV感染的慢性化、肝组织损伤以及干扰素的抗病毒效果密切相关。本文就趋化因子及其受体在慢性丙型肝炎的发病机制,以及趋化因子对干扰素抗病毒疗效的影响进行综述。

Chemokines are a family of small molecular weight proteins having similar structure and function, and having cells with chemotaxis effect. Researches demonstrate that ehemokines are associated with HCV chronic infection, liver injury and the anti - viral efficacy of IFN. Here the roles of chemokines and their receptors in the pathogenesis of chronic hepatitis C and the anti - viral efficacy of IFN are reviewed.