噬血细胞综合征患者血清促红细胞生成素表达水平的研究

Expressions of serum erythropoietin in hemophagocytic syndrome patients

目的:探讨血清促红细胞生成素(EPO)在噬血细胞综合征(HPS)患者中的表达水平及临床意义。方法:收集22例HPS患者及15例健康人血清,分别采用酶联免疫吸附(ELISA)方法检测其血清EPO水平,并与各实验室检查指标进行相关性分析。结果:HPS患者组血清EPO水平显著高于健康对照组,差异有统计学意义(P<0.01),感染相关性HPS患者和肿瘤相关性HPS患者血清EPO水平差异无统计学意义(P>0.05)。检测HPS患者血清EPO水平与采血当日红细胞、血红蛋白、血肌酐、尿素氮、三酰甘油、纤维蛋白原、铁蛋白、NK细胞活性、sCD25水平的相关性,发现其与铁蛋白水平呈正相关关系,与其他各项实验室指标均无相关性。结论:HPS患者血清EPO升高可能与贫血、肿瘤有关,但由于炎性因子抑制了EPO对贫血反应的敏感性,所以与血红蛋白之间并无相关关系。EPO在疾病的发生、发展中可能起到一定作用。

Objective：To investigate the expressions of serum erythropoietin（EPO） in hemophagocytic syndrome（HPS） patients and to evaluate its clinical significance.Method：Serum concentration of EPO in HPS patients and 15 healthy controls were measured by enzyme-linked immunosorbent assay（ELISA）.Then the correlation between EPO and laboratory indicators was analyzed.Result：The levels of serum EPO in 22 cases of HPS were significantly higher than in control group（P0.01）and the difference was not statistically significant between infection-associated HPS and tumor-associated HPS（P0.05）.EPO level in HPS patients showed positive correlation with serum ferritin after EPO levels and red blood cell counts,hemoglobin counts,serum creatinine,urea nitrogen,triglyceride,fibrinogen,ferritin,NK cell activity and sCD25 levels were detected at the same day.Conclusion：High level of EPO in HPS patients may be associated with anemia and tumor,and there was no correlation between EPO and hemoglobin because of inhibition effect of inflammatory factors.These data indicated that serum EPO may play certain roles in the pathogenesis and the progress of HPS.