曲唑酮联合心理疏导治疗功能性消化不良50例

Trazodone Combined Psychological Counseling for Treating 50 Cases of Functional Dyspepsia

目的观察曲唑酮联合心理疏导治疗功能性消化不良的疗效。方法将100例确诊为功能性消化不良的患者分为心理治疗组和对照组各50例,两组均给予雷尼替丁胶囊1粒、1日2次,多潘立酮片10 mg、1日3次,均饭前口服。心理治疗组加用心理疏导和曲唑酮50 mg,1日2次,早、晚饭后口服,疗程4周。结果心理治疗组与对照组治疗1,2,4周后总有效率分别为68.33%,85.00%,95.00%和41.67%,51.67%,58.33%,两组疗效差异非常显著(P<0.01)。治疗4周后心理治疗组上腹胀痛、上腹烧灼和上腹不适、早饱、嗳气等症状改善积分总有效率分别为94%,93%,93%,明显高于对照组的56%,56%,55%(P<0.01)。结论心理疏导和抗抑郁药对伴有焦虑和抑郁症状的功能性消化不良患者治疗效果十分显著,值得临床医师重视和推广。

Objective To evaluate the effect of trazodone combined psychological counseling in the treatment of functional dyspepsia.Methods A hundred patients diagnosed functional dyspepsia were divided into the psychological treatment group and the control group,50 cases in each group.Two groups were given Ranitidine Capsule,twice daily,domperidone 10 mg,3 times daily,all orally taking before meals.The psychological treatment group was added the psychological counseling and trazodone 50 mg,twice daily,all by orally taking after breakfast and supper,with the treatment course of 4 weeks.Results The total effective rates after 1,2,4 weeks of treatment were 68.33%,85.00%and 95.00%in the psychological treatment group and 41.67%,52.00%and 58.33%in the control group,showing very significant difference between them（P 0.01）.The total effective rates in the symptomatic improvement scores of epigastric pain,epigastric burning sensation and epigastric discomfort,early satiety and belching after 4-week treatment were 94%,93%and 93%in the psychological treatment group,which were significantly higher than 56%56%and 55%in the control group（P 0.01）.Conclusion The psychological counseling and antidepressant drugs for treating functional dyspepsia complicating anxiety and depression symptoms has significant effects and is worthy of clinical doctors taking into account and being clinically popularized.