息斯敏致小鼠心律失常的实验研究

The experimental study of proarrhythmic effect of hismanal on mice

目的:研究息斯敏(阿司咪唑)对小鼠的致心律失常作用,了解其致心律失常的类型,推测其致心律失常的机理,为临床用药提供实验依据。方法:小鼠灌胃息斯敏,记录30min、60min、90min、120min、150min、180min小鼠心电图的变化。结果:息斯敏可引起多数小鼠出现缓慢性心律失常,心电图表现为心率减慢,P-R间期和Q-T间期延长,随剂量增加,甚至可引起完全性房室传导阻滞和窦性停搏。少数情况也会出现窦性、室性心动过速等快速性心律失常。结论:息斯敏可引起小鼠多型性心律失常,以缓慢性心律失常为主,快速心律失常少见,并随剂量增加,死亡率提高。

Objective：The present study was designed to investigate the proarrhythmic effects and patterns of Hismanal on mice,and speculate the underlying mechanism.Method：Mice were administered intragastrically with Hismanal.Electrocardiogram was recorded at different time points including 30 min、60 min、90 min、120 min、150 min、180 min,respectively.Result：Hismanal cause bradyarrhythmias in most mice.Electrocardiogram showed that heart rates slowed,P-R interval and Q-T interval prolonged,even complete atrioventricular block and sinus arrest happened with the increase of Hismanal dose.Tachyarrhythmias such as sinus tachycardia or ventricular tachycardia could occur in a few of mice.Conclusion：Various arrhythmias can be induced by Hismanal in mice,among which the main types of arrhythmia is bradyarrhythmias.Tachyarrhythmia is rare.Moreover,the mortality of mice increases with the increase of Hismanal dose.