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罗哌卡因腰麻在剖宫产术中的量效关系 被引量:9

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摘要 目的:确定剖宫产患者罗哌卡因蛛网膜下腔阻滞的量效关系。方法:择期剖宫产者100例,随机、双盲分为4组。于L3~4间隙蛛网膜下腔穿刺成功后,分别注射罗哌卡因10(A组)、15(B组)、20(C组)、25mg(D组)。采用针刺法测定感觉阻滞平面,改良Bromage评分法测定下肢运动神经阻滞程度,VAS评分评估患者疼痛程度,记录麻醉后不良反应。采用Probit法计算50%和95%患者镇痛有效的罗哌卡因剂量(ED50和ED95)及其95%可信区间。结果:罗哌卡因的ED50及其95%可信区间为16.7 mg和14.1~18.8 mg,ED95及其95%可信区间为26.8 mg和23.6~34.1 mg。非麻醉期间,感觉及运动阻滞的持续时间和运动阻滞的程度与剂量明显相关。麻醉后不良反应少。结论:剖宫产术患者罗哌卡因腰麻的ED50和ED95分别为16.7 mg和26.8 mg。在剖宫产麻醉中,罗哌卡因是一种合适的腰麻药物。
作者 喻金政
出处 《现代医学》 2011年第6期718-719,共2页 Modern Medical Journal
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