壤塘县藏族成人大骨节病膝关节单次注射玻璃酸钠的疗效观察

Therapeutic Effect of Sodium Hyaluronate Intraarticular Injection in Treatment of Adult Patients with Kaschin Beck Disease in Rangtang

目的研究壤塘县藏族成人大骨节病膝关节损害患者单次注射玻璃酸钠的疗效和副作用。方法壤塘县藏族成人大骨节病膝关节损害28例,单侧膝关节注射一次玻璃酸钠2.0 ml,注射前及注射后第1、3和8周分别采用VAS疼痛评分、关节活动度和藏区大骨节病日常生活和劳动能力量表评价治疗效果。结果 VAS评分注射前,注射后1、3和8周分别为5.9、3.0、3.2和4.9分;关节活动度增加16°,有效率100%,注射8周后治疗效应开始降低。对日常生活及劳动能力改善不明显。结论膝关节单次玻璃酸钠注射可明显缓解藏族成人大骨节病患者膝关节疼痛,疼痛缓解时间持续2个月。

Objective To observe the therapeutic effect and side effects of sodium hyaluronate（SH） intraarticular injection in the treatment of adult patients with Kaschin Beck disease in Rangtang,Sichuan province.Methods Twenty eight cases of adult Kaschin Beck disease received once the SH intraarticular injection.The clinical manifestation of all patients before the treatment,1 week later,3 weeks later and 2 months later after injection were recorded and evaluated.Results After the treatment,all 28 patients had good control in the pain of knees,and the range of knee movements was a little better,but the activity of daily living was not improved significantly.The effective rate was 100%.Conclusion For the adult patients with Kaschin Beck disease,the SH intraarticular injection is a perfect procedure to treat the pain of knee,but is not effective to improve the activity of daily living.The therapeutic effect of the SH intraarticular injection can last 2 months.