脑白质病变相关性轻度认知功能障碍患者神经心理学特征分析

Charactistics of cognitive impairment in the patients with both mild cognitive impairment and white matter lesions

目的观察脑白质病变(WML)对轻度认知功能损害(mild cognitive impairment,MCI)患者神经心理学的影响。方法 WML-MCI患者和健康对照者进行常规核磁共振及神经心理学检查,观察WML对MCI患者神经心理学的影响,并对其机制进行探讨。结果 WML-MCI组与对照组相比,高血压、糖尿病和冠心病比例明显增高;词语流畅性测验、积木测验和画钟测验评分均明显降低(P<0.05);而2组间MMSE、数字广度测验和词语延迟回忆测验评分无明显差异。结论 WML影响MCI患者的认知功能,主要表现为视空间及执行功能。血管危险因素是MCI发病的危险因素。

Objective To investigate the effect of white matter lesions（WML） on neuropsyehological assessment in mild cognitive impairment（MCl）. Methods Fifty-one elderly persons with WMI-MCI and 60 elderly normal people underwent conventional MRI and neuropsychological assessment. The correlations between white matter lesions and cognitive functions were analyzed. Results The subjects with WML-MCI had higher prevalence of hypertension and diabetes and coronary artery disease than control subjects. All the scores of verbal fluency, block test and clock-drawing test in WML-MCI group were lower than those in control group（P^0. 05）. The scores of MMSE, the digit span test and delayed memory test were not sigtlificantly different between WMI-MCI and control subjects. Conclusion WML influences cognitive functions in MCI, Vascular risk factors are risk factors for presence of MCI.