大剂量甲基强的松龙治疗重症病毒性脑炎临床观察

Clinical observation of large dosage of methylprednisonlone in treating severe viral encephalitis

目的探讨甲基强的松龙对重症病毒性脑炎的疗效。方法将28例重症病毒性脑炎患者随机分为2组:治疗组应用大剂量甲基强的松龙冲击治疗;对照组给予常规地塞米松治疗。治疗后比较2组患者的发热、抽搐、意识障碍和脑膜刺激征及恢复时间。结果甲基强的松龙治疗组症状和体征恢复正常的时程缩短,与对照组比较,差异有统计学意义(P<0.01)。结论大剂量甲基强的松龙冲击疗法可迅速缓解症状,缩短病程,减少后遗症,提高治愈率。

Objective To investigate the clinical effect of large dosage of methylprednisolone（MP） in treating severe encephalitis. Methods Twenty-eight patients with severe encephalitis were allocated to two groups. The treatment group received large dose of methylprednisolone, control group accepted dexamethasone. The coincidence time of clinical manifestations, such as fever, convulsion, conscious disturbance and meningeal irritation sign, were compared. Results The recovery time of clinical manifestation was significantly lower in treatment group. There was a significant difference compared with control group （P〈0.01）. Conclusion The pulse therapy of MP can fast remit symptom, shorten disease course, lessen sequel, and increase curative rate for severe encephalitis patients.