喉癌中maspin与p53表达的相关性

Correlation between maspin and p53 proteins in laryngeal carcinoma

目的观察喉癌中maspin和p53蛋白的表达,探讨maspin和p53在喉癌发生、发展中的作用。方法采用免疫组化法检测78例喉鳞癌组织中maspin和p53蛋白。结果在喉癌中maspin阳性表达率为55.1%(43/78),maspin表达下降与病理分化程度低、淋巴结转移有关。p53阳性表达率为58.9%(46/78)。在maspin阳性表达的43例喉癌中,p53阳性表达率为79.1%,maspin阴性表达的喉癌中,p53阳性表达率为34.3%,差异有统计学意义(P<0.05)。Spearman等级相关分析显示,maspin在喉癌组织中的表达与p53呈负相关性,有统计学意义(rs=-0.381,P=0.006)。结论 maspin在喉癌的发生发展中起一定抑制作用。喉癌中maspin表达与p53表达呈负相关,maspin可能是p53的效应基因。

Objective To detect expression of maspin protein and to explore the correlation between maspin and p53 proteins in laryngeal carcinoma, and explore their roles in the development of cancer. Method Maspin and p53 protein expressions were evaluated in 78 patients with laryngeal squamous cell carcinoma（LSCC） by immunohistochemical stai- ning. Results LSCC expressed maspin protein in 43/78 （55.1% ） cases. The depression of maspin protein was related to low cell differentiation and lymph node metastasis. The gross positive expression rate of p53 was 58.9% （46/78）. In the maspin-positive LSCC, p53 expression was found in 34/43 cases （79.1% ）, while among the maspin-negative ca- ses, the p53 expression rate was 34.3%. There was significant difference between the two groups. Spearman rank cor- relation analysis showed a strong inverse correlation between maspin expression and p53 （P 〈 0.05）. Conclusions Ex- pression of rnaspin inhibits the development of LSCC. It is inversely correlated with p53, suggesting that maspin is an effector of mutant-type p53.