肾病综合征患者凝血功能检测的结果分析

Analysis of hypercoagulable state in patients with nephrotic syndrome

目的:通过对肾病综合征患者凝血指标的结果分析,探讨其在肾病综合征中的临床意义。方法:采用法国STA-COMPACT全自动凝血分析仪,对43例正常人和59例肾病综合征患者的凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、PLT、血小板压积(PCT)、平均血小板体积(MPV)、血小板分布宽度(PDW)指标的检测与分析,并对结果进行两两比较。结果:肾病综合征组与正常对照组比较,FIB、PLT、MPV、PCT明显升高,APTT明显缩短,均差异有统计学意义(均P<0.05),而TT、PT、PDW变化不明显,差异无统计学意义(P>0.05)。结论:肾病综合征患者存在高凝状态,故凝血功能的检测对肾病综合征病情分析、血栓形成的临床诊断、药物治疗、预后均有重要的参考价值。

Objective：To investigate the indicators of blood coagulation in patients with nephrotic syndrome and analyze its clinical significance in nephrotic syndrome.Method：The prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fiber Fibrinogen（FIB）,platelet count（PLT）,platelet hematocrit（PCT）,mean platelet volume（MPV）and platelet distribution width（PDW）of 43 normal subjects and 59 patients with nephrotic syndrome were detected by French STA-COMPACT automatic blood coagulation analyzer and compared.Result：Compared nephrotic syndrome group with normal control group,FIB,PLT,MPV and PCT were significantly higher（P0.05）,and APTT was significantly shorter（P0.05）,which differences were significant.While the TT,PT and PDW did not change significantly（P0.05）.Conclusion：The patients with nephrotic syndrome are in hypercoagulation state,so the detection of blood condition would be important reference value for pathogenetic condition analysis,the clinical diagnosis of thrombosis,drug therapy and prognosis of nephrotic syndrome patients.