老年患者代谢异常病史与遗忘关系的初步研究

Relationship between metabolic disorders and mild cognitive impairment in elderly patients

目的:探讨代谢异常病史与遗忘型轻度认知功能障碍(aMCI)的关系。方法:136名患者被分为遗忘型轻度认知功能障碍(aMCI)组(n=93)与对照组(n=43)。对两组患者进行代谢病史的回顾性分析,同时以干化学法检测空腹血糖(FBG)、糖化血红蛋白(HbA1c),以酶联免疫吸附法检测白介素-6(IL-6)。结果:糖尿病史、高血压史及男性吸烟史在两组之间具有统计学差异(P<0.05);高脂血症史、总体吸烟史在两组之间无统计学差异(P>0.05);FBG及HbA1c水平在两组之间无显著性差异;aM-CI组IL-6的水平[(78.57±2.37)pg/ml]显著高于对照组[(72.48±4.74)pg/ml,P<0.05]。结论:高血压、糖尿病、男性吸烟史等危险因素可能通过IL-6相关的炎症状态参与aMCI的发生与发展。

Objective: To investigate the potential relationship between amnestic mild cognitive impairment(aMCI) and metabolic disorders(MD).Methods: Totally,136 persons were included and divided into aMCI group(male/female=44/49,average age=73.01 ± 7.12 years) and control group(male/female=25/18,average age=73.77 ± 7.37 years).The histories of MD were all recorded.Fasting blood glucose(FBG) and glycated hemoglobin(HbA1c) were detected by dry chemistry method.Interleukin 6(IL-6) was detected by enzyme-linked immunosorbent assay.Results: IL-6 was highly expressed in the aMCI group[(78.57 ± 2.37) pg/ml],compared with control group[(72.48 ± 4.74)pg/ml,P < 0.05].There was no significant difference between the two groups in FBG and HbA1c(P > 0.05).Furthermore,the diabetes and hypertension were proved as the common risk factors(P < 0.05).Interestingly,smoking is a risk factor only in male aMCI patients.Conclusion: The present study demonstrated that the history of diabetes,hypertension and male smoking placed an important part in the generation of aMCI.The reason might partly be ascribed to the inflammation state caused by the risk factors.