OLF方案联合HCPT腹腔灌注热化疗治疗胆系肿瘤疗效观察

The clinical effects in patients with biliary tract cancer treated with OLF combined with HCPT administrated as intraperitoneal perfusion hyperthermia

目的:观察OLF[O:草酸铂(L-OHP);L:醛氢叶酸(LV);F:氟尿嘧啶(5-Fu)]方案联合羟基喜树碱(HCPT)腹腔灌注热化疗治疗晚期胆系肿瘤的近期疗效。方法:24例晚期胆系肿瘤患者采用OLF方案静脉化疗:L-OHP 85 mg/m2,CF 130 mg/m2静脉滴注2 h,第1、8天给药;5-Fu 200 mg/m2快速静脉滴注30 min,后给予5-Fu 1 000 mg/m2静脉泵入22 h,第1、8天给药。静脉化疗间歇期配合HCPT 15 mg腹腔灌注化疗,静脉化疗和腹腔化疗时均辅以热疗。28 d为1个周期,按RECIST评价疗效,同时综合评估临床受益反应指标:疼痛、体力状况及体重变化。结果:24例患者均化疗2个周期以上,其中完全缓解0例,部分缓解7例(29.2%),稳定8例(33.3%)。16例(66.7%)患者临床获益,生活质量提高。不良反应主要为骨髓抑制和消化道反应。结论:OLF方案联合HCPT腹腔灌注热化疗治疗晚期胆系肿瘤具有较好的近期疗效,不良反应能耐受,值得进一步研究。

Objective： To observe the clinical effects in patients with biliary tract cancer treated with OLF（L-OHP,LV,5-Fu） combined with hydroxycamptothecin（HCPT） which was administrated as intraperitoneal perfusion hyperthermia.Methods： Twenty-four patients were given chemotherapy as well as intraperitoneal chemotherapy combined with hyperthermia.The curative effects were estimated according the criterea of RECIST and the clinical benefit response rate（CBR） was evaluated.The CBR refers to pain,physical status and body weight.Results： There was no complete response among all the patients.Partial response was observed in 7 patients（29.2%） and stable disease was 33.3%.As to CBR,16 patients of total（66.7%） achieved the clinical benefit response and their quality of life was improved.The toxicities were marrow depression and alimentary tract reactions.Conclusion： This thermo-chemotherapy comprehensive regimen was an effective and safty methods for patients with advanced biliary tract cancer.