输卵管组织LIF及其受体LIFR的表达与输卵管妊娠的关系

The correlation between the occurrence of tubal pregnancy and the expression levels of LIF and LIFR in oviduct tissues

目的:探讨白血病抑制因子(LIF)及其受体(LIFR)与输卵管异位妊娠的关系。方法:采用免疫组化技术检测11例非孕组和36例输卵管异位妊娠组输卵管组织中LIF和LIFR的表达水平,半定量分析其在各组间的表达差异。结果:无论是在输卵管腺上皮还是间质中,LIF在非孕组和异位妊娠组间的表达无明显差别;但是在输卵管腺上皮中,LIFR的表达异位妊娠组高于非孕组(P<0.05);而在间质中,LIFR的表达输卵管妊娠组明显低于非孕组(P<0.01)。结论:LIFR的异常表达可能与输卵管异位妊娠的发生密切相关。

Objective： To explore the correlation between the occurrence of tubal pregnancy and the expression level of leukemia inhibitory factor（LIF） and LIF receptor（LIFR）.Methods： Semi-quantitative analysis of LIF and LIFR by immunohistochemistry was performed in 11 fallopian tubal tissues of non-pregnant group,and 36 of tubal pregnancy group,respectively.Results： The LIFR expression level in fallopian tubal epithelium cells of tubal pregnancy group was significantly higher than that of non-pregnant group.While the LIFR abundance in interstitial cells of tubal pregnancy group was significantly lower than that of non-pregnant group.However,no significant difference of LIF abundance was found between two groups.Conclusion： Aberrant expression of LIFR in oviduct tissues might be involved in the ectopic implantation process of tubal pregnancy.