多氧取代环己烯酮(醇)衍生物的合成及表征

Synthesis and Characterization of Derivatives of PolyoxygenatedCyclohexenone(Cyclohexenol)

为寻找具有抗肿瘤活性的化合物,对天然的具有抗肿瘤活性的环己烯类化合物进行结构修饰和改造,设计合成了3个多氧取代环己烯酮(醇)类化合物,其结构均经过IR1、H NMR和HRMS表征。对化合物(3R,4S,5R)-1-苯甲酰氧亚甲基-3,4,5-三羟基-1-环己烯(7)的烯丙醇选择性氧化的条件进行了探索,最佳条件:活性MnO2为氧化剂,在苯中回流10 min,产率达到20.6%。

In order to search compounds with better anti-tumor activities,cyclohexenes,which were extracted from nature and had anti-tumor activities,were modified and three polyoxygenated cyclohexone（cyclohexenol） deriatives were designed and synthesized.Their structures were identified by IR,1H NMR and HR MS.The conditions for the selective oxidation of allyl alcohol of（3R,4S,5R）-1-benzoyloxymethylen-3,4,5-trihydroxy-1-cyclohexene（7） were explored.The optimum condition was that compound 7 was refluxed in dry benzene for 10 min with MnO2 as oxidant,and the yield was 20.6%.