离子液体中合成2-溴-4-甲氧基苯胺的研究

Synthesis of 2-Bromo-4-methoxyaniline in Ionic Liquid

研究了在离子液体中对甲氧基苯胺经溴化合成2-溴-4-甲氧基苯胺的方法。以98.2%的收率得到质量分数为99.5%的2-溴-4-甲氧基苯胺。探讨了不同溴化剂及其用量、反应温度、反应时间等因素对溴化反应的影响。该方法原料易得,反应条件易于控制,收率高,离子液体可以重复使用,对环境友好。

A method for synthesis of 2-bromo-4-methoxyaniline in ionic liquid was introduced.The title compound was prepared from p-methoxyaniline via bromination.2-Bromo-4-methoxyaniline was obtained in 98.2% yield and 99.5% purity.The effect of various brominating agents and their amounts,reaction temperature and reaction time on the bromination reaction was investigated.The new procedure for preparing 2-bromo-4-methoxyaniline has the advantages of easy source of material,good yield,simple operation and environmental benignity.Ionic liquid can be reused.