期刊文献+

间苯三酚联合奥曲肽治疗伊立替康致重度迟发性腹泻的临床观察

下载PDF
导出
摘要 目的 观察间苯三酚联合奥曲肽治疗伊立替康所致重度迟发性腹泻的疗效.方法回顾性分析2例间苯三酚联合奥曲肽治疗伊立替康所致重度迟发性腹泻,应用洛哌丁胺无效患者的病例.结果联合间苯三酚治疗24h后,2例患者的大便次数及性状均有恢复,36h后1例患者大便明显好转,48h后2例患者的大便性状和次数基本恢复正常.4d内2例患者的大便完全恢复正常.结论 对于伊立替康所致重度迟发性腹泻可尝试间笨三酚联合奥曲肽治疗,但其有效性及安全性仍需临床大样本进一步研究.
作者 王文辉
出处 《潍坊医学院学报》 2011年第4期292-294,共3页 Acta Academiae Medicinae Weifang
  • 相关文献

参考文献8

  • 1Limonti A,Gelibter A,Pavese I,et al.New approaches to prevent intestinal toxicity of irinotecan-based regimens[J].Cancer Treat Rev,2004,30 (6):555 - 562.
  • 2Fujiwara Y,Minami H.An overview of the recentp rogress inirinotecan pharmacogenetics[J].Pharm acogenomics,2010,11 (3):391 -406.
  • 3Dranitsar G,Shah A,Spirovski B,et al.Severe diarrhea in patients with advanced-stage colorectal cancer receiving FOLFOX or FOLFIRI chemotherapy:the development of a riskp rediction tool[J].Clin Colorectal Cancer,2007,6 (5):367 - 373.
  • 4Stringer AM,Gibson R J,Logan RM,et al.Chemother-Apy-induced diarrhea is associated with changes in the luminal environment in the DA rat[J].Exp Biol Med(Maywood),2007,232(1):96 - 106.
  • 5Wisinski K,Benson A.Chemotherapy-induced mucositis:focusing on diarrhea[J].J Support 0ncol,2007,5 (6):270 - 271.
  • 6Wadkins RM,Hyatt JL,yoon KJ,et al.Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of iriontecan-induced diarrhea:synthesis,quantitative structure-activity relationship analysis,and biological activity[J].Mol Pharmacol,2004,65(6):1336 - 1343.
  • 7Yoon K J,Hyatt JL,Morton CL,et al.Characterization of inhibitors of specific carboxylesterases:development of carboxylesterase inhibition for translational application[J].Mol Cancer Ther,2004,3 (8):903 -909.
  • 8Takasuna K,Hagiwara T,Watanabe K,et al.Optimalantidiarrhea treatment for antitumor agent irinotecan hydrochloride (CPT-11)-induced delayed diarrhea[J].Cancer Chem Other Pharmacol,2006,58 (4):494 - 503.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部