AECOPD氧化应激与肺功能、最大呼吸肌力动态变化相关性研究

Correlative relationship among oxidative stress and lung function,maximal respiratory muscle strength in patients with COPD in acute exacerbation period

目的研究AECOPD患者氧化应激与肺功能、最大呼吸肌力动态变化的相关性。方法 ELISA检测47例COPD急性加重期患者血清丙二醛(MDA)、谷胱甘肽(GSH)、氧化型谷胱甘肽(GSSG)、超氧化物歧化酶(SOD)浓度,与其第一秒钟用力呼气容积(FEV1)、用力肺活量(FVC)、最大吸气压(MIP)年下降值进行相关性分析。结果 MDA与FEV1年下降值呈正相关,GSH、GSH/GSSG与FEV1年下降值呈负相关,GSH与MIP年下降值呈负相关。结论 COPD急性加重期氧化/抗氧化失衡加速COPD的肺功能下降和呼吸肌力的减弱。

Objective To study the correlative relationship among oxidative stress and lung function, maximal respiratory muscle strength in patients with COPD in acute exacerbation period. Methods Serum concentrations of malondialdehyde （ MDA）, glutathione GSH）, glutathione disulfide （ GSSG）, superoxide dismutase （ SOD） were detected in 47 patients with COPD in acute exacerbation period through ELISA, which were correlatively analyzed to yearly-decreased value of forced expiratory volume in one second （ △FEV） ）, forced vital capacity （ △FVC）, and maximal inspiratory pressure （AMIP）. Results There were a positive correlative relationship between MDA and A FEV1, a negatively correlated relationship between GSH ,GSH/GSSG and △ FEV1 respectively, a negatively correlated relationship between GSH and a MIP. There was no other significant relationships reported. Conclusion Oxidants/antioxidants imbalance deteriorates lung function and maximal respiratory muscle strength in patients with COPD in acute exacerbation period.