显微镜下多血管炎3例伴文献复习

Three case reports of microscopic polyangiitis and documentary review

目的分析显微镜下多血管炎(MPA)的临床特点,提高对MPA的认识,以提高诊断水平。方法回顾性分析我科确诊的3例MPA患者的临床表现、实验室检查、病理改变、治疗及预后。结果 3例患者均以肺部症状就诊,伴肾脏受累,MPO-ANCA均阳性。结论 MPA临床表现无特异性,大多具有多脏器受累的特点,以肾脏及肺脏病变最为多见,易误诊,抗中性粒细胞胞质抗体(ANCA)对MPA的诊断有重要价值。

Objective To analyze the clinical characteristic of microscopic polyangiitis （MPA） , elevate realization about MPA and improve diagnosis. Methods The clinical manifestation, laboratory examination, pathological changes, treatment and prognosis of 3 cases of MPA were retrospectively analyzed. Results All of the 3 patients came with lung symptom accompanied by kidney trouble. All patients showed positive MPO-ANCA. Conclusion The clinical manifestation of has no specificity, mostly accompanied by muhi-viscera trouble in which the lesions of lung and kidney is the most frequent, and hence MPA is led to misdiagnosis. Antineutrophil cytoplasmic antibody （ANCA） will be of great value to MPA＇s diagnosis.