支气管舒张试验对AECOPD小气道功能影响

The effect Of bronchodilation test on small airway function in AECOPD patients

目的探讨支气管舒张试验对慢性阻塞性肺疾病急性加重期(AECOPD)小气道功能影响。方法分析我院2008年1月至2011年4月38例AECOPD患者,行支气管舒张试验,FEV1、FEF 50%、FEF 75%、MMEF 75/25%行配对t检验。结果支气管舒张试验在AECOPD及支气管舒张试验阳性组小气道功能均存在显著差异;在支气管舒张试验阴性组,FEV1、FEF 50%存在显著差异,但FEF 75%、MMEF 75/25%无差异。结论支气管舒张试验可改善AECOPD患者小气道功能,但在支气管舒张试验阴性组小气道功能指标FEF 75%、MMEF 75/25%无改善。

Objective To assess the effect of bronchodilation test on small airway tunetion in acute exacerbatinn chronic obstrctive pulmonary disease （AECOPD） patients. Methods In 38 patients with AECOPD in-hospital from January 2008 to April 2011 , Bronehodilation test was determined, and FEVt , FEF 50% , FEF 75% , MMEF 75/25% were observed and analyzed as pairs by t-test. Results The parameters of small airway tunction had significanl differences in AECOPD and the positive group; there were significant differences in FEV1 and FEF 50% , but there was no significant difference in FEF 75% and MMEF 75/25% in the negative group. Conclusion Small airway function was improved by bronehodilation test in AECOPD, but EF 75% , MMEF 75/25% were not improved obviously in the negative group.