廊坊市结核病耐药现状分析

Analysis of drug resistance trend on tuberculosis in Lang fang city

目的掌握廊坊市结核病细菌学耐药水平及其治疗效果分析。方法采用整群抽样方法,河北省在我市抽取7个监测调查点,课题期间新登记的涂阳结核病人作为入选病例,采用比例法对INH,RFP,EMB,SM,OFX,KM进行药物敏感试验。结果总纳入245例,进行药敏试验234例,供药敏分析225例,总耐药率为43.6%,耐多药(MDR-TB)率11.6%,广泛耐多药(XDR-TB)率0.4%;新患者耐药率43.0%,耐多药率7.3%;复治患者耐药率为46.9%,耐多药率37.5%,广泛耐多药率3.1%。结论廊坊市结核分枝杆菌的耐药率高于全国平均水平,结核病控制工作不容忽视。

Objective The study was conducted to investigate bacteriological drug-resistance and therapeutic effect of TB in Lang fang city. Methods Seven clusters of Lang fang in Hebei Province were randomly selected with cluster smupling method. All the new smear positive TB cases during the survey period were involved. Proportion method was used for drug sensitivity test to INH, RFP, EMB, SM, OFX, and KM. Results 245 cases were included. 234 cases had drug sensitivity tests, among which the results of 225 eases were analyzed. The overall drug resistance rate, the multi-drug resistance rate and the wide range of multi-drug resistance rate were 43.6%, 11.6% and 0. 4%, respectively. The drug resistance rate and the multi-drug resistance rate among new cases were 43.0% and 7.3%. The drug resistance rate, the multi-drug resistance rate and the wide range of multi-drug resistance rate among retreated smear positive cases were 46. 9%, 37.5 % and 3.1%, respectively. Conclusions The prevalence of drug resistant tuberculosis is higher in Lang fang than the national average level, and the quality of TB control performance need to be strengthened.