肺癌患者血清Survivin和VEGF的表达及其临床意义

Significance of serum survivin and VEGF levels in lung cancer

目的通过检测Survivin和VEGF在非小细胞肺癌患者血清中的含量,探讨非小细胞肺癌诊断、分级的临床意义。方法采用酶联免疫吸附法(ELISA)对51例非小细胞肺癌患者血清中Survivin和VEGF的表达水平及30例正常健康人血清Survivin和VEGF水平进行检测。结果非小细胞肺癌患者血清Survivin和VEGF水平明显高于健康对照组(P<0.01);Survivin和VEGF的表达呈正相关(P<0.01);Survivin和VEGF的表达与患者性别、年龄、肿瘤分期、病理分型、淋巴结转移等无关(P>0.05)。结论检测非小细胞肺癌患者血清Survivin和VEGF的水平,对病情的发生和发展、具有重要的临床意义。

Objective To detect the serum survivin and VEGF levels in non-small cell lung cancer patients and to explore the diagnosis and classification of non-small cell lung cancer. Methods The survivin and VEGF levels in 51 non-small cell lung cancer patients and 30 healthy controls were detected by ELISA. Results Levels of survivin and VEGF in non-small cell lung cancer patients significantly increased compared to the healthy controls （ P 〈 0. 01 ）, and the contents between survivin and VEGF were positively correlated （ P 〈 0. 01 ）. The expression of survivin and VEGF unrelated to clinical data such as patients＇gender, ages, tumor staging, tumor histopathological features, and lymph nodes metastasis （ P 〉 0. 05 ）. Conclusion The detection of survivin and VEGF in non-small cell lung cancer patients has an important clinical significance in studying the occurrence and progress, clinical diagnose of lung cancer.