复方阿嗪米特肠溶片联合多潘立酮治疗老年功能性消化不良腹胀临床观察

Clinical study on compound azintamide plus domperidone in treatment of abdominal distention in elders with functional dyspepsia

目的观察复方阿嗪米特与多潘立酮联合使用对功能性消化不良症状的改善程度,同时记录不良事件。方法将120例门诊就诊的老年功能性消化不良患者纳入本研究。分别给予复方阿嗪米特肠溶片2片/次,每日3次,加多潘立酮10 mg/次,每日3次,餐前30 min服用4周。观察服药前后食欲不振、腹胀、腹痛、嗳气、恶心、腹泻、便秘等症状的积分和药物副作用的情况。结果治疗4周后腹胀症状积分显著低于治疗前。未观察到严重的药物相关性不良反应。结论复方阿嗪米特联合多潘立酮治疗老年功能性消化不良安全有效。

Objective To study the efficacy and safety of compound azintamide plus domperidone for treatment of abdominal distention in elders with functional dyspepsia. Methods A total of 120 elderly patients with functional dyspepsia were enrolled in this study. They were ran- domly allocated into trial group （ Group A, n = 60） and control group （ Group B, n = 60 ）. Patients in group A took 2 tablets of compound azintamide 3 times a day after meal in addition to domperidone 10 mg 3 times per clay 30 rain before meal for 4 weeks. Patients in group B were only given with domperidone 10 mg 3 times per day for 4 weeks. The changes in symptom scores of anorexia, abdominal distention, upper abdominal pain or discomfort, belching, nausea and other adverse events were recorded. Results After treatment for 4 - weeks, the average index scores of abdominal distention in trial group were significantly lower than those before treatment. The improvement of average index scores was more promi- nent in group A than group B. No servere drug side effect was noted during the treatment course. Conclusion Compound azintamide plus domperidone showed effectiveness and safety in treatment of elderly patients with functional dyspepsia.