白塞综合征128例临床分析

Clinical analysis of 128 patients with Behcet's disease

目的:总结白塞综合征的临床特点,提高对白塞综合征的认识。方法:对收集的128例白塞综合征患者的临床资料进行回顾性分析,对其临床表现、实验室检查、男女间的差异进行比较。结果:128例患者中男女比例约1.5:1,发病年龄多为20～39岁(78.3%)。平均发病年龄(32.0±12.1)岁,病程1～22年,平均病程5年。其中不完全型80例(62.5%),完全型48例(37.5%)。口腔溃疡是最常见的临床表现(128例,:100%),其次为皮肤损害(115例,89.8%),生殖器溃疡(92例,71.9%),针刺反应阳性(70例,54.7%),眼部损害(38例,29.7%)。人白细胞抗原(HIA)-B51阳性率为29.5%(18/61)。口腔溃疡为最常见的首发表现(91例,71.1%),其次为皮肤损害(69例,53.9%),外阴溃疡(61例,30.9%),眼部损害(15例,11.7%)。男女间在发病率、皮损类型、眼部损害、神经系统损害及相关实验室检查差异显著。结论:白塞综合征累及多系统,临床表现多变,男女间差异明显。

Objective： To observe the clinical characteristics of patients with Behcet＇s disease （BD）. Methods： Clinical data were collected from 128 patients with （BD） admitted to Dermatology Department of Tenth People＇s Hospital of Tongji Univer- sity during 1996 to 2009. The clinical manifestations were analyzed retrospectively, including its prevalence by gender and time, involvement in the varied organs and systems and the differences between male and female patients. Results： Mean age at onset was （32.0±12.1） years old, with an average length of clinical course of 5 （1-22） years. Oral ulcer was the most often found in all the 128 （100%） patients, and then followed by skin lesions in 115 cases （89.8%）, genital ulcer in 92 cases （71.9%）, positive for isomorphic reaction in 70 cases （54.7%）, and eyes involvement in 38 cases （29.7%）. Among 61 cases 18 （29.5%） were HLA-B51 positive. Oral ulcer, as the initial sign, was found in 91 of 128 cases, and then followed by skin le- sions in 69 cases, genital ulcer in 61 cases, and eyes involvement in 15 cases. The incidence, the types of skin lesions, eyes or nerves involvement and related lab findings were significant different between male and female patients. Conclusion： Multiple organs and systems could be involved in BD with diversity of clinical manifestations. There is significant difference between male and female patients in certain aspects of clinical manifestations. The knowledge of BD should be well improved so as to decrease the rate of misdiagnoses.