皮肤粒细胞肉瘤

A case of skin granulocytic sarcoma

报告1例皮肤粒细胞肉瘤。患者男,50岁。3年前不慎被竹片刺伤,皮损处出现结节,逐渐增大、增多,沿淋巴管方向分布于双上肢。曾行外周血常规及骨髓穿刺检查均正常。入院行组织病理检查示低分化髓细胞髓外(皮肤和皮下脂肪组织)浸润。免疫病理示髓过氧化物酶(MPO)(++)、Ki67(++)、CD43(+)。组织病理诊断为皮肤粒细胞肉瘤。确诊后行骨髓穿刺提示急性粒细胞白血病(AML,M2)。转血液科接受化疗,化疗无效很快死亡。

A case of skin granulocytic sarcoma （GS） is reported. A 50-year-old man had his skin pricked with bamboo, and then some nodes appeared and gradually increased in size and number over both upper limbs along the lymphatic ves- sels. The bone marrow aspiration and peripheral blood cell count underwent in another hospital showed normal. Biopsy revealed an extramedullary （cutaneous and subcutaneous fat tissue） infiltration of poorly differentiated myeloid cells in our hospital. Immunohistoehemical test showed positive to MPO（＋＋）, Ki67（＋＋） and CD43（＋）. The diagnosis of skin granulocytic sarcoma was conformed. Further bone marrow aspiration suggested acute myeloid leukemia （AML） （M2）. Then the patient was received treatment of chemotherapy, but the prognosis was unsatisfactory and he soon died.