3种材质输液容器对盐酸博来霉素A2和B2的吸附性考察

Study on Adsorbability of Bleomycin Hydrochloride A2 and B2 in 3 Different Kinds of Intravenous Solution Containers

目的:考察非聚氯乙烯(PVC)多层共挤膜输液袋、聚丙烯(PP)输液瓶和玻璃瓶3种材质输液容器对盐酸博来霉素的吸附性。方法:取相同量的盐酸博来霉素加入3种包装材质的2种输液(5%葡萄糖注射液和5%葡萄糖氯化钠注射液)中,混合均匀后分别于0、6、24、48h时取样,采用高效液相色谱法测定药物浓度,与0h时浓度相比计算相对百分含量。结果:48h时,溶媒分别为5%葡萄糖注射液和5%葡萄糖氯化钠注射液时,在PP输液瓶中,盐酸博来霉素A2、B2相对百分含量分别为90.81%、89.56%和55.65%、82.4%;而在另2种材质包装的2种溶媒中,盐酸博来霉素A2、B2相对百分含量均大于95%。结论:3种材质中,以PP输液瓶对盐酸博来霉素吸附性最强,尤其是在以5%葡萄糖氯化钠注射液为溶媒时;临床使用该药时应避免选用该材质输液瓶。

OBJECTIVE： To investigate the adsorbability of non-polyvinly chloride （NPVC） infusion bags, polypropylene （PP） infusion bags and glass bottles to bleomycin hydrochloride, respectively. METHODS： Bleomycin hydrochloride was separately added into above infusion bags or bottles containing 5% Glucose injection （GS） or 5% Glucose sodium chloride injection （GNS）. Samples of drug solutions were collected at 0, 6, 24, 48 hours and analyzed by HPLC methods. Relevant percentage content was calculated, compared with concentration at 0 h. RESULTS： At 48 h, solvent were 5% GS and 5% GNS, and relevant per- centage contents of bleomycin hydrochloride A2 and B2 in PP bottles were 90.81%, 89.56% and 55.65%, 82.4%. Relevant percentage contents of bleomycin hydrochloride A2 and B2 in other 2 kinds of container were all more than 95%. CONCLUSION： Among 3 kinds of materials, PP infusion bottle shows the strongest adsorbability, especially for 5 % GNS as solvent. PP should not be used for bleomycin hydrochloride.