安普贴外敷预防外周静脉置入中心静脉导管致化疗性静脉炎的疗效

Therpeutic Effects of Algoplaque External Application in Preventing Chemotherapeutic Phlebitis Induced by Peripherally Inserted Central Catheter

目的探讨安普贴外敷预防外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)致化疗性静脉炎的效果。方法选择2010年1-12月在泰安市肿瘤防治院放疗二科住院,需行PICC化疗的恶性肿瘤患者100例作为研究对象。按随机数字表法将其分为观察组和对照组,每组50例。置管成功后,观察组患者采用安普贴(10cm×10cm)外固定,换药1次/周;对照组患者采用透明敷贴(10cm×10cm)外敷固定,换药2次/周。连续观察3～6个月,比较两组患者化疗性静脉炎的发生比例及严重程度。结果观察组中有6例患者发生化疗性静脉炎,占12.0%;对照组中有21例患者发生化疗性静脉炎,占42.0%,经比较差异有统计学意义(χ2=11.34,P<0.01)。观察组中3级以上的静脉炎发生率为0,3、4级静脉炎主要发生在对照组。结论安普贴能有效预防PICC所致化疗性静脉炎的发生。

Objective To investigate the effect of Algoplaque external application in preventing chemother- apeutic phlebitis induced by peripherally inserted central catheter（PICC）. Methods From January 2010 to December 2010,100 cancer patients undergoing PICC chemotherapy in the hospital were randomly divided into experimental group and control group, with 50 patients in each group. After the successful insertion catheters,the patients of the experimental group were fixed with Algoplaque（10 cm ×10 cm） at the vein puncture site and the dressings were changed once a week. The patients of the control group were fixed with 3M film（10cm× 10cm） and the dressings were changed for two times a week. Then these patients were observed for 3 to 6 months and the incidence and severity of chemotherapeutic phlebitis were com- pared between the two groups. Results The incidence rates of phlebitis in the experimental group and the control group were 12 % （6/50） and 42 % （21/50） respectively. There was significant differences on the inci- dence rates between these two groups（x2=11. 34,P〈0. 01）. No phlebitis（grade≥3） occurred in the experimental group and phlebitis （grade 3- 4） occurred mainly in the control group. Conclusion Algo- plaque can effectively prevent chemotherapeutic phlebitis induced by PICC.