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二肽基肽酶抑制剂异军突起 被引量:4

Rising market of Dipeptidyl peptidase Ⅳ(DPP-Ⅳ) inhibitor
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摘要 二肽基肽酶(DPP-Ⅳ)抑制剂是治疗Ⅱ型糖尿病的新药,因其无低血糖、体重增加以及胃肠道相关问题而备受青睐。本文综述DPP-Ⅳ抑制剂上市品种的市场表现及后续品种的开发。 Dipeptidyl peptidase IV(DPP-IV) inhibitor has been used as a new therapeutic option for the treatment of type II diabetes. Its rapid rise in popularity is due to the favorable profile such as no hypoglycemia, no weight gain and no gastrointestinal problems. This paper reviews the market performance and the development of DPP-IV inhibitors.
作者 蔡皓
出处 《世界临床药物》 CAS 2011年第12期754-757,共4页 World Clinical Drug
关键词 DPP-Ⅳ抑制剂 降糖药 医药市场 DPP-IV inhibitor anti-diabetic drug pharmaceutical market
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同被引文献78

  • 1Peng Cho Tang.Design and synthesis of DPP-4 inhibitor for the treatment of type 2 diabetes[J].Chinese Chemical Letters,2010,21(3):253-256. 被引量:3
  • 2丁虹伶,程训民,骆合德,冯金忠.二甲双胍对老年2型糖尿病患者的疗效及安全性[J].东南国防医药,2005,7(2):112-113. 被引量:11
  • 3欧阳凌云,杨刚毅.二肽基肽酶Ⅳ抑制剂治疗糖尿病的研究进展[J].国外医学(药学分册),2006,33(2):111-113. 被引量:1
  • 4王璐,邸阜生.肠促胰岛素类似物和DPP-Ⅳ抑制剂在2型糖尿病治疗中的作用[J].医学综述,2007,13(1):25-27. 被引量:6
  • 5Cheng D. Prevalence, predisposition and prevention of type II diabetes [J]. Nutr Metab, 2005, (2): 29.
  • 6Gershell L. Type 2 diabetes market [J]. Nat Rev DrugDiscov, 2005, 4(5): 367-368.
  • 7Nauck M A, Heimesaat M M, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers [J]. J Clin Endoerinol Metab, 2002, 87(3): 1239-1246.
  • 8Farilla L, Bulotta A, Hirshberg B, et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets [J]. Endocrinology, 2003, 144(12): 5149-5158.
  • 9Meier J J, Gallwitz B, Salmen S, et al. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon- like peptide 1 in patients with type 2 diabetes [J]. J Clin EndocrinolMetab, 2003, 88(6): 2719-2725.
  • 10Verdich C, Flint A, Gutzwiller J P, et al. A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans [J]. J Clin Endocrinoz Metab, 2001, 86(9): 4382-4389.

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