成骨与骨髓瘤
摘要
在多发性骨髓瘤(MM)患者中,由于破骨细胞(osteoclasts,OC)与成骨细胞(osteoblast,OB)失衡,导致约80%的患者出现严重的溶骨性病变。现已证实.骨髓瘤细胞抑制成骨,而溶骨性骨病也正是成骨失活的一个表现。
出处
《内科理论与实践》
2011年第6期459-462,共4页
Journal of Internal Medicine Concepts & Practice
参考文献37
-
1Bataille R,Chappard D,Marcelli C,et al.Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma[J].J Clin Invest,1991,88(1):62-66.
-
2Drake M,Ng A,Kumar S,et al.Increases in serum levels of Dickkopf 1 are associated with alterations in skeletal microstructure in monoclonal gammopathy of undetermined significance[C].The 31st Annual Meeting of the American Society for Bone and Mineral Research.2009,USA:Denver.
-
3Landgren O,Kyle RA,Pfeiffer RM,et al.Monoclonal gammopathy of undetermined significance(MGUS)consistently precedes multiple myeloma:a prospective study[J].Blood,2009,113(22):5412-5417.
-
4Barillé S,Collette M,Bataille R,et al.Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin[J].Blood,1995,86(8):3151-3159.
-
5Tian E,Zhan F,Walker R,et al.The role of the Wntsignaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma[J].N Engl J Med,2003,349(26):2483-2494.
-
6Oshima T,Abe M,Asano J,et al.Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor,sFRP-2[J].Blood,2005,106(9):3160-3165.
-
7Giuliani N,Colla S,Morandi F,et al.Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation[J].Blood,2005,106(7):2472-2483.
-
8Standal T,Abildgaard N,Fagerli UM,et al.HGF inhibits BMP-induced osteoblastogenesis:possible implications for the bone disease of multiple myeloma[J].Blood,2007,109(7):3024-3030.
-
9Ehrlich LA,Chung HY,Ghobrial I,et al.IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma[J].Blood,2005,106(4):1407-1414.
-
10Pennisi A,Ling W,Li X,et al.The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth[J].Blood,2009,114(9):1803-1812.
-
1孙强生,张青田.骶骨溶骨性病变:附16例报告[J].新疆医学,1989,19(4):213-215.
-
2姜兆侯,谢力健,杨志忠,马强华,张书盛,彭英政,林淦河,邱六涛,王天保,华逢涛,张德生,宋国余,慕均成,黄宝生,吴红,魏若林,张钰.乳腺癌骨转移100例临床影像学分析[J].临床放射学杂志,1995,14(1):42-44. 被引量:7
-
3陈玉宝.多发性骨髓瘤溶骨性病变机制的研究进展[J].国外医学(输血及血液学分册),1996,19(3):163-166.
-
4J.D.Goldsmith,P.J.Horwich,S.K.Shetty,M.G.Hochman,向贤宏.影响影像引导下芯针穿刺骨骼软组织病变诊断率因素的探讨[J].国际医学放射学杂志,2008,31(A06):491-491. 被引量:26
-
5闫敏(综述),崔树德(审校),江泽飞(审校).乳腺癌骨转移研究进展[J].国际肿瘤学杂志,2009,36(8):596-599.
-
6左孟华,姜振宇,刘冬莉.帕米磷酸二钠治疗多发性骨髓瘤的溶骨性病变的临床观察[J].吉林医学,2001,22(4):215-216.
-
7甄平.原发性甲状旁腺功能亢进症致全身多发溶骨性病变二例报告[J].中国骨与关节杂志,2013,2(9):535-537.
-
8魏波,顾强荣,杜小涛,李栋,王黎明.甲状腺滤泡癌多发胸椎转移一例[J].中国骨与关节杂志,2014,3(5):398-400. 被引量:2
-
9谢海雁,张薇,周道斌,沈悌.慢性粒细胞白血病并发溶骨性病变一例[J].中华血液学杂志,2006,27(3):157-157. 被引量:1
-
10庞芳芳,沈洪涛,何明,董克君,武绍勇,窦亮,史颜君,张爽,王小明,赵庆章,杨旭冉,徐永宁,蓝小淅,蔡力,姜山.Walker256乳腺癌细胞骨转移动物模型的建立[J].中国原子能科学研究院年报,2013(1):106-106.