急性胰腺炎病因及相关因素分析

Analysis on Pathogeny and Correlative Factors of Acute Pancreatitis

目的探讨近10年来本院急性胰腺炎（AP）的病因及相关因素特点,提出早期的干预措施。方法对我院近10年来668例确诊为急性胰腺炎的住院病人,以五年为单位分为两组,以病因、性别、年龄为变量进行回顾性统计学分析。结果两组患者胆石症、酒精性、高脂血症、暴饮暴食均为急性胰腺炎常见病因。两组比较提示近几年急性胰腺炎发病人数明显增加,高脂血症及酒精性为病因增加明显,其差异比较均有统计学意义（P〈0.05）;两组中男性发病率比女性明显高,其差异比较有统计学意义（P〈0.05）;两组在30~59岁年龄段AP发病率明显增加,≥60岁年龄段发病率减少,其差异比较均有统计学意义（P〈0.05）。结论胆石症、高脂血症、酒精性、暴饮暴食仍是急性胰腺炎常见病因,近几年高脂血症及酒精性为病因均较前增多,男性发病率增高,在30~59岁年龄段患者增多,≥60岁的年龄段患者减少,故对不同原因及不同人群应采取不同预防措施。

Objective To explore the pathogeny and correlative factors of acute pancreatitis, put forward the early intervention measures. Methods 668 cases of patients confirmed acute pancreatitis in the past ten years in our hospital were divided into two groups in five years as the unit; the pathogenesis, gender and age were analysed statistically and retrospectively. Results Patients＇ cholelithiasis, alcoholic, hyperlipidaemia, and engorgement were common causes of acute pancreatitis in the two groups. Comparison between the two groups indicated an obvious increase of the incidence of acute pancreatitis caused by alcoholic and hyperlipidaemia; male had higher morbidity than female in both groups; the age between 30 and 59 had a significant increase incidence; the diffrence above were all statistically significant （P 0.05）. Conclusion Cholelithiasis, hyperlipidaemia, alcohol and engorgement are the common factors of acute pancreatitis, and hyperlipidaemia and alcoholic factors increased more obvious in recent years. Male between 30 and 59 have a higher incidence, but reduce at the age over 60, so we should take different preventive measures for different reasons and populations.