重新认识促性腺激素释放激素激动剂的降调节作用

New insight into pituitary down regulation

在这里，我们非常感谢益普生公司提供给我们很好的学习交流的平台!在第七届达菲林体外受精（IVF）训练营中，我提出“降调节新理念”的主题，我们都很熟悉此概念，但此概念在不断地更新，每年我们均在研讨这一概念，每年均有一些新的变化，我们谈论此问题是从不同的角度在研讨!

Pituitary down regulation with gonadotropin-releasing hormone agonist （GnRH-a） has greatly improved the pregnancy outcomes in the clinical practice of assisted reproduction. empirical data accumulated in the clinical practice and related studies, pituitary down regulation With the has been found to have multiple benefits. The effect of GnRH-a is not only confined to its regulation on the hypothalamic-pituitary-ovarian axis, but also on many other systems and/or organs via paracrine regulation. In addition to the intended effect of curbing premature luteinizing hormone （LH） surge, pituitary down regulation can also synchronize the development of oocytes and improve the endometrial receptivity. The 7th annual Diphereline IVF training campus focuses on the re-understanding of pituitary down-regulation, and hopefully helps to optimize the down-regulation protocols and dosage in the practice. One of the new features in this training session is the introduction of case discussion, which facilitates the sharing of experiences of experts around the country.