TAT介导PRDX5,6蛋白转导防止高糖视网膜周细胞毒性作用

TAT-mediated peroxiredoxin 5,6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes

高血糖诱发氧化应激可引起糖尿病视网膜病变(diabetic retinopathy,DR)中的周细胞凋亡。哺乳动物6个过氧化物酶(peroxiredoxin1-6,PRDX1-6)是一新的抗氧化蛋白家族,通过控制活性氧(reactive oxygen species,ROS)的水平负性调节氧化应激引起的细胞凋亡。我们就TAT介导的PRDX5,6蛋白转导防止高葡萄糖诱发视网膜周细胞的毒性作用作一综述。

Hyperglycemia-induced oxidative stress can cause pericytes apoptosis seen in diabetic retinopathy（DR）.The six mammalian peroxiredoxins1-6（PRDX1-6） are a new family of antioxidant proteins,which negatively regulate oxidative stress-induced apoptosis by controlling the level of reactive oxygen species（ROS）.This paper reviewed the TAT-mediated PRDX5,6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes.