血浆脑钠肽在心房纤颤患者中应用的临床意义分析

Clinical Significance of Plasama Brain Natriuretie Peptide in Patients with Atrial Fibrillation

目的观察心房纤颤(房颤)对血浆脑钠肽(BNP)水平的影响并探讨其临床意义。方法采用美国博适-Triag干式快速定量(心力衰竭/心肌梗死)诊断仪床旁测定86例心功能正常房颤患者及30例无器质性心脏病窦性心律患者BNP水平。对房颤患者进行药物复律,测定复律前后血浆BNP水平。结果房颤患者BNP水平显著高于无器质性心脏病窦性心律患者(P<0.01)。房颤组中,复律成功组复律后的BNP水平显著下降(P<0.01);复律成功组复律前BNP水平明显低于未复律成功组(P<0.01)。结论房颤是影响BNP分泌的重要因素,BNP水平是预测房颤复律效果的重要指标,复律后BNP水平显著下降。

Objective To observe the plasma brain natriuretie peptide levels in patients with atrial fibrillation(AF)and its clinical significance.Methods The plasma BNP levels were measured at bedside in 86 cases of atrial fibrillation with normal heart function and 30 cases of normal sinus rhythm without structural heart diseases,using Biosite trige dry quantitative determination.Drugs on patients with atrial fibrillation to sinus rhythm,determination of plasma BNP levels before and after cardioversion.Results BNP levels were significantly higher than that of atrial fibrillation without structural heart diseases in sinus rhythm group(P<0.01).Of AF group,the sinus rhythm after successful cardioversion group of BNP level was significantly decreased(P<0.01);successful cardioversion to sinus rhythm group,BNP levels were significantly lower than before cardioversion success group(P<0.01).Conclusion Atrial fibrillation is an important factor affecting the secretion of BNP,BNP level is an important indicator to predict the effect of cardioversion in AF,after cardioversion BNP levels significantly decreased.