期刊文献+

大肠癌患者血清IL-8水平检测及临床意义 被引量:1

下载PDF
导出
摘要 目的探讨大肠癌患者血清白细胞介素-8(IL-8)水平及其临床意义。方法 2010年09月~2011年09月期间,诊治60例大肠癌患者,采用酶联免疫吸附实验(ELISA)方法,检测患者术前、术后血清IL-8水平,并与60例健康对照组相比较。结果与对照组相比,大肠癌组术前、术后的IL-8水平明显增高,P<0.05,差异有统计学意义;与术前相比(95.12±12.34),大肠癌组术后IL-8水平明显降低(62.18±10.28),P<0.05,差异有统计学意义。处于I、II、III、IV期的IL-8水平两两比较,P<0.05,差异都具有统计学意义。而且从I期到IV期,大肠癌患者血清IL-8水平也逐步升高。结论血清IL-8水平与DDuke’s分期有显著相关性,与大肠癌的发生、发展及预后也有关,可作为临床诊断及判定预后的指标之一。
作者 王志刚
出处 《当代医学》 2012年第1期36-37,共2页 Contemporary Medicine
  • 相关文献

参考文献6

二级参考文献39

  • 1Luppi F, Longo AM,de Boerw I, et al. Interleukin-8 stimulates cell proliferation in non small cell lung cancer through epidermal growth factor receptor transactivation [J]. Lung Cancer,2007,56(1):25-33.
  • 2Murphy C, MeGurk M, Pettigrew J, et al. Nonapical and cytoplasmic expression of interleukin-8 CxcR1 ,and CxcR2 correlates with cell proliferation and microvessel density in prostate cancer [J]. Clin Cancer Res, 2005,11(11) : 4117-4127.
  • 3Lokshin AE, Winans M, I.andsittel D, et al. Circulating IL-8 and anti-IL-8 autoantibody in patients with ovariancancer[J]. Gynecol Oncol,2006,102(2) :244-251.
  • 4Macri A, Versaci A, Loddo S, et al. Serum levels of interleukin 1 beta,interleukin 8 and turnout necrosis factor alpha as markers of gastric cancer[J]. Biomarkers, 2006,11 (2) :184-193.
  • 5[1]Yoshimura T,Matsushima K,Oppenheim JJ,el al.Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes:partial characterization and separation from in-terleukin 1 (IL 1)[J].J Immunol,1987,139 (3):788-793.
  • 6[2]Murphy C,McGurk M,Pettigrew J,et al.Nanapical and cytoplasmic ex-pression of interleukin-8,CXCR1,and CXCR2 correlates with cell pro-liferation and microvessel density in prostate cancer[J].Clin Cancer Res,2005,11 (11):4117-4127.
  • 7[3]Ben Y,Poon RT,Tsui HT,et al.Interleukin-8 serum levels in patients with hepatoceUular carcinoma:correlations with clinicopathological fea-tures and prognosis[J].Clin Cancer Res,2003,9(16):5996-6001.
  • 8[4]Tas F,Duranyildiz D,Ognz H,et al.Serum vascular endothelial growth factor (VEGF) and bcl-2 levels in advanced stage non-small cell lung cancer[J].Cancer Invest,2006,24(6):576-580.
  • 9[5]Macri A,Versaci A,Loddo S,et al.Serum levels of interleukin lbeta,in-terleukin 8 and tumour necrosis factor alpha as markers of gastric cancer[J].Biomarkers,2006,11 (2):184-193.
  • 10[6]Lokshin AE,Winans M,Landsittel D,et al.Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer[J].Gynecol Oncol,2006,102(2):244-251.

共引文献9

同被引文献11

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部