武汉地区497例少、弱、畸精子或无精子症患者细胞遗传学分析

Cytogenetic analysis on 497 oligoasthenoteratozoospermia and azoospermia

目的分析男性不育患者染色体核型。方法对497例少弱畸精子或无精子症患者进行外周血G显带染色体核型分析,并跟踪核型正常者其助孕结局。结果检出染色体核型异常62例,异常率为12.47%(62/497)。其中少、弱、畸、精子症患者306例,核型异常率12.4%(38/306),无精子症患者191例,染色体核型异常率为12.7%(24/191)。结论染色体核型异常是导致男性不育的重要原因。

Objective： To analyze the karyotype of male infertility patients.Methods：Peripheral blood of patients with G-banding karyotype was analysed on 497 cases of oligoasthenoteratozoospermia and azoospermia,and track those who assisted reproductive outcome with normal karyotype.Results： There were 62 cases of Chromosome abnormalities detected,the rate was 12.47%（62/497）,They include 306 cases of Oligoasthenozoospermia and teratospermia,and the abnormal rate of karyotype was 12.4%（38/306）,191 cases of azoospermia,the abnormal rate of karyotype was 12.7%（24/191）.Conclusions： Chromosome abnormalities were important leading cause of male infertility.