抑制素A水平与中孕期筛查标志物及影响因素的相关性分析

The study on the relationship between inhibin-A level and second-trimester markers and influencing factors

目的评估中孕期母亲血清中抑制素A水平与其它血清标志物和影响因素的相关性。方法选择2008年3月-2010年12月在广州市妇女儿童医疗中心接受中孕期"三联"唐氏筛查的单胎妊娠孕妇共2802例。采用全自动酶联免疫化学发光分析法检测血清中抑制素A水平。结果 (1)在正常妊娠孕妇血清样本,抑制素A与中孕期血清标志物freeβ-hCG、AFP相关且有统计学意义(P<0.01),尤其与freeβ-hCG的相关性最高(r=0.502),而与uE3相关性没有统计学意义(P>0.05);在胎儿唐氏综合征孕妇血清样本,抑制素A与freeβ-hCG、AFP和uE3的相关性均没有统计学意义(P>0.05)。(2)135例阴道流血和40例糖尿病孕妇血清中抑制素A水平与无合并症的孕妇没有差异(P均>0.05)。孕期母亲体重与血清中抑制素A水平呈负相关(r=-0.101),并有统计学意义(P<0.01)。男性胎儿孕妇血清中抑制素A水平低于女性胎儿孕妇并有统计学意义(P<0.01)。结论血清中抑制素A水平与中孕期标志物freeβ-hCG的相关性最高,与母亲体重呈负相关性,且与胎儿性别相关,但不受孕期母亲阴道流血或糖尿病的影响。

Objective： To investigate the correlationship of second-trimester serum inhibin-A level and other markers and influencing factors.Methods： 2802 cases received second-trimester screening between 15 weeks and 20 weeks 6 days was included.Maternal serum inhibin-A concentration was determined by automatic enzyme linked immunosorbent chemiluminescence assay.Results：（1） In the normal pregnancy,there is significant relationship between inhibin-A and free β-hCG,AFP（P0.01）,but not uE3（P0.05）.In the affected pregnancy,there is no significant relationship between inhibin-A and free β-hCG,AFP and uE3（P0.05）.（2）There is no difference between inhibin-A level in women with vaginal bleeding or gestational diabetes mellitus and women with no complications（P0.05）.Serum inhibin-A levels was negatively correlated with maternal weight（r=-0.101,P0.01）.There is significant difference of inhibin-A level between women with female and male fetus（P0.01）.Conclusions： There is significant correlationship between serum inhibin-A level and free β-hCG,maternal weight and fetal gender,but not with maternal vaginal bleeding or gestational diabetes mellitus.