利尿合剂治疗顽固性心力衰竭120例疗效观察

The clinical efficacy of Diuretic mixture in the treatment of refractory heart failure in 120 cases

目的观察利尿合剂治疗顽固性心力衰竭患者临床疗效及安全性。方法将120例顽固性心力衰竭患者完全随机分为治疗组和对照组各60例，2组患者均给予利尿剂、血管紧张素转换酶抑制剂、硝酸酯类药物、控制感染及纠正水、电解质紊乱和洋地黄等治疗。治疗组加用利尿合剂，观察7d，对比2组的临床疗效。结果治疗组与对照组总有效率分别为91．7％（55／60）、71．7％（43／60），总有效率差异有统计学意义（x2=8．541，P〈0．05）。结论．顽固性心力衰竭患者常规治疗效果不佳，联合应用利尿合剂可显著提高疗效，安全经济，值得推广。

Objective To summarize the efficacy and safety of diuretic mixture in the treatment of refractory heart failure. Methods One hundred and twenty patients with refractory heart failure were randomized into treatment group and control group. All the patients were treated with digitalis, diuretics, ACEI, nitrates, and strategies to control infection and correct water and electrolyte disorders. The treatment group was given additional diuretic mixture and was monitored for 7 days. Results In the treatment group and control group, the overall response rates were 91.7% （55/60） and 71.7% （43/60）, respectively. The difference was significant （ x2 = 8. 541,P 〈 0. 05）. Conclusions The patients with heart failure and refractory to conventional treatment will benefit from diuretic mixture treatment,with the advantages of safety and economy.